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Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | Page 6-9 | Shekhar Kumta, Carol Lau, K C Wong. Authors: Shekhar Kumta [1], Carol Lau [1], K C Wong [2]. [1] Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, [2] Department of Orthopaedics& Traumatology, The Prince of Wales Hospital, Hong […]

Giant Cell Tumor Symposium Part 1

May 10, 2017

Vol 3 | Issue 1 | May- Aug 2017 | page:2 | Dr. Mandip Shah Author: Dr. Mandip Shah [1]. [1] Sparsh Orthopedic Oncology Clinic. Medicare Building 9th Floor, , B/H Town Hall, Ashram Road, 380006 – Ahmedabad., India Address of Correspondence Dr. Mandip Shah Sparsh Orthopedic Oncology Clinic. Medicare Building 9th Floor, , B/H Town Hall, […]

Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

September 10, 2017

Giant Cell Tumor Symposium Part 1

May 10, 2017

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Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | Page 6-9 | Shekhar Kumta, Carol Lau, K C Wong.

Authors: Shekhar Kumta [1], Carol Lau [1], K C Wong [2].

[1] Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong,
[2] Department of Orthopaedics& Traumatology, The Prince of Wales Hospital, Hong Kong.

Address of Correspondence
Dr. Shekhar Kumta,
103-E, Learning Resource Centre, Block A, Prince of Wales Hospital, Shatin, Hong Kong.
Email: shekharkumta@gmail.com

Abstract

GCT of bone is a locally aggressive bone-destroying tumor. The primary neoplastic tumor cell is a RANKL over expressing cell that drives osteoclast recruitment and activation, ultimately leading to bone resorption at the site of the lesion. Osteoclast driven destruction in GCT may be ameliorated with the use of drugs such as Bisphophonates, which target Osteoclasts as well as the primary neoplastic stromal cells. Denusomab, is a monoclonal antibody against RANKL and it has a dramatic effect on Osteoclasts. Adjuvant therapies have reduced recurrence rates in GCT of bone, but uncertainties remain as to the optimum dose-intensity of the drugs and the duration of treatment.
Keywords: Tumor, bone destruction, Giant Cell Tumor of Bone.

References

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How to Cite this article: Kumta S, Lau C, Wong K C. Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice. Journal of Bone and Soft Tissue Tumors Sep-Dec 2017;3(2): 6-9..

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Giant Cell Tumor Symposium Part 1

May 10, 2017

Vol 3 | Issue 1 | May- Aug 2017 | page:2 | Dr. Mandip Shah

Author: Dr. Mandip Shah [1].

[1] Sparsh Orthopedic Oncology Clinic. Medicare Building 9th Floor, ,
B/H Town Hall, Ashram Road, 380006 – Ahmedabad., India

Address of Correspondence
Dr. Mandip Shah
Sparsh Orthopedic Oncology Clinic. Medicare Building 9th Floor, ,
B/H Town Hall, Ashram Road, 380006 – Ahmedabad., India
Email: mandipshah@gmail.com

Giant Cell Tumor Symposium Part 1

Giant cell tumor is one of the commonest bony tumor that is not only encountered by Orthopaedic Oncology surgeons but by general orthopaedic surgeons. This is the reason weneed to keep ourselves updated about what new is happening with this specific bone tumor. We have conceptualise this symposium in Journal of Bone and soft tissue tumors in two parts. This first part has two articles. The first article is by Dr Bhavin Jhankaria and his team on Current concepts of imaging in GCT. This article brings up all the latest updates from a radiologist point of view and also keeps in mind the practical issues faced by the surgeons. The second article is an update on intralesional curettage by Dr Manish Agarwal. Intralesional Curettage is the most important and most commonly used surgical technique for treatment of GCT and Dr Agarwal details the surgical techniques as well as the current updates on the concept and results. With these two articles most impoartant areas of GCT are covered. The aspect of adjuvant therapies and other complex topics will be covered in the next part of the symposium Please write to us regarding your suggestions and opinions.

How to Cite this article: Shah M. Giant Cell Tumor Symposium Part 1. Journal of Bone and Soft
Tissue Tumors May- Aug 2017; 3(1):2.

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Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

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Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

Authors: Shekhar Kumta [1], Carol Lau [1], K C Wong [2].

Abstract

References

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Giant Cell Tumor Symposium Part 1

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Authors: Shekhar Kumta [1], Carol Lau [1], K C Wong [2].

Abstract

References

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Author: Dr. Mandip Shah [1].

Giant Cell Tumor Symposium Part 1

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Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

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