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Giant Cell Tumor Symposium Part 2

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | page:1 | Dr. Mandip Shah. Author: Mandip Shah [1]. [1] Sparsh Orthopedic Oncology Clinic. Medicare Building 9th Floor, , B/H Town Hall, Ashram Road, 380006 – Ahmedabad., India. Address of Correspondence Dr. Mandip Shah Sparsh Orthopedic Oncology Clinic. Medicare Building 9th Floor, , B/H Town Hall, Ashram […]

Histopathology of Giant-cell Tumor of Bone – Current Concept

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | Page 2-5| Sanjeev Shah. Authors: Sanjeev Shah [1]. [1] Department of Pathology, Unipath Laboratory Specialty Ltd, Beside JMC House, Ahmedabad, Gujarat, India. Address of Correspondence Dr. Sanjeev Shah, 102, First floor, Sanoma Plaza, Opp. Parimal Garden, Beside JMC House, Ellisbridge, Ahmedabad – 380006, Gujarat, India. E-mail: […]

Giant Cell Tumor Symposium Part 2

September 10, 2017

Histopathology of Giant-cell Tumor of Bone – Current Concept

September 10, 2017

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Giant Cell Tumor Symposium Part 2

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | page:1 | Dr. Mandip Shah.

Author: Mandip Shah [1].

[1] Sparsh Orthopedic Oncology Clinic. Medicare Building 9th Floor, , B/H Town Hall, Ashram Road, 380006 – Ahmedabad., India.

Address of Correspondence
Dr. Mandip Shah
Sparsh Orthopedic Oncology Clinic. Medicare Building 9th Floor, , B/H Town Hall, Ashram Road, 380006 – Ahmedabad., India
Email: mandipshah@gmail.com

Giant Cell Tumor Symposium Part 2

We are back with the second part of the Giant Cell Tumor Symposium for Journal of Bone and Soft Tissue Tumors.
Two very important aspects are covered in this part. First is the histopathological concepts regarding GCT. There is lot of new knowledge that is available in recent years and that has significantly impacted the diagnosis, management and prognosis of GCT. Histopathological assessment play a major role in terms of determining the behaviour of GCT. Current understanding of molecular pathogenesis of GCTB particularly RANK on osteoclast-like GCs and RANKL on stromal cells and development of newer agents such as denosumab and INF-α has tremendously impacted management of patients with GCTB. This aspect is elaborated in the first article. The second article builds on these concepts and describes how this is used for adjuvent therapy for GCTB. Authors of both the authors have taken tremendous effort to make both these articles good and current. Also these two now conclude the GCT Symposium and cover all aspect of GCTB
Please write to us regarding your suggestions and opinions

Regards
Dr. Mandip Shah

How to Cite this article: Shah M. Giant Cell Tumor Symposium Part 2. Journal of Bone and Soft Tissue Tumors Sep-Dec 2017; 3(2):1.

(Abstract Full Text HTML) (Download PDF)

Histopathology of Giant-cell Tumor of Bone – Current Concept

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | Page 2-5| Sanjeev Shah.

Authors: Sanjeev Shah [1].

[1] Department of Pathology, Unipath Laboratory Specialty Ltd, Beside JMC House, Ahmedabad, Gujarat, India.

Address of Correspondence
Dr. Sanjeev Shah,
102, First floor, Sanoma Plaza, Opp. Parimal Garden, Beside JMC House, Ellisbridge, Ahmedabad – 380006, Gujarat, India.
E-mail: dcp72002@yahoo.com

Abstract

GCTB is a primary osteolytic bone tumor which can recurrence, undergo metastasis, and malignant transformation. Current understanding of molecular pathogenesis of GCTB particularly RANK on osteoclast-like GCs and RANKL on stromal cells and development of newer agents such as denosumab and INF-α has tremendously impacted management of patients with GCTB.
Keywords: Giant-cell tumor of bone histopathology, current concept.

References

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8. Schoedel KE, Greco MA, Stetler-Stevenson WG, Ohori NP, Goswami S, Present D, et al. Expression of metalloproteinases and tissue inhibitors of metalloproteinases in giant cell tumor of bone: An immunohistochemical study with clinical correlation. Hum Pathol 1996;27:1144-8.
9. Hoch B, Inwards C, Sundaram M, Rosenberg AE. Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty cases. J Bone Joint Surg Am 2006;88:1998-2008.
10. Dhillon MS, Prasad P. Multicentric giant cell tumour of bone. ActaOrthopBelg 2007;73:289-99.
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15. Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet 2013;45:1479-82.
16. Akpalo H, Lange C, Zustin J. Discovered on gastrointestinal stromal tumour 1 (DOG1): A useful immunohistochemical marker for diagnosing chondroblastoma. Histopathology 2012;60:1099-106.
17. Cleven AG, Briaire-de Bruijn I, Szuhai K, Bovee JV. DOG1 expression in giant-cell-containing bone tumours. Histopathology 2016;68:938-45.
18. Althof PA, Ohmori K, Zhou M, Bailey JM, Bridge RS, Nelson M, et al. Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: Aberrations of 17p mapped to 17p13.2 by fluorescence in situhybridization. Mod Pathol 2004;17:518-25.
19. Oliveira AM, Perez-Atayde AR, Dal Cin P, Gebhardt MC, Chen CJ, Neff JR, et al. Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes. Oncogene 2005;24:3419-26.
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How to Cite this article: Shah S. Histopathology of Giant-cell Tumor of Bone – Current Concept. Journal of Bone and Soft Tissue Tumors Sep-Dec 2017;3(2): 2-5.

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Giant Cell Tumor Symposium Part 2

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Histopathology of Giant-cell Tumor of Bone – Current Concept

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Giant Cell Tumor Symposium Part 2

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Histopathology of Giant-cell Tumor of Bone – Current Concept

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Giant Cell Tumor Symposium Part 2

Author: Mandip Shah [1].

Giant Cell Tumor Symposium Part 2

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Histopathology of Giant-cell Tumor of Bone – Current Concept

Authors: Sanjeev Shah [1].

Abstract

References

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Author: Mandip Shah [1].

Giant Cell Tumor Symposium Part 2

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Authors: Sanjeev Shah [1].

Abstract

References

(Abstract Full Text HTML) (Download PDF)

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Like this:

Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

Important Information

Journal of Bone and Soft Tissue Tumors (JBST) License