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Analysis of X-ray Patterns in Infection and Tumor

May 10, 2021/in Vol 7 | Issue 2 | May-Aug 2021 /by jbstadmin

Cases Series | Volume 7 | Issue 2 | JBST May – August 2021 | Page 5-8 | Dominic Puthoor. DOI:10.13107/jbst.2021.v07i02.47 Author: Dominic Puthoor[1] [1]Department of Orthopaedic Oncologist, Amala Institute of Medical Sciences, Thrissur, Kerala, India. Address of Correspondence Dr. Dominic Puthoori, Department of Orthopaedic Oncologist, Amala Institute of Medical Sciences, Thrissur, Kerala, India. E-mail: […]

Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

May 10, 2021/in Vol 7 | Issue 2 | May-Aug 2021 /by jbstadmin

Case Report | Volume 7 | Issue 2 | JBST May- August 2021 | Page 1-4 | Abigail R. Tud, Cesar D. Dimayuga. DOI:10.13107/jbst.2021.v07i02.46 Author: Abigail R. Tud[1], Cesar D. Dimayuga[1] [1]Department of Orthopedics, The Medical City, Ortigas Avenue, Pasig City, Philippines 1605. Address of Correspondence Dr. Abigail R. Tud, Musculoskeletal Tumor Unit, Philippine Orthopedic […]

Analysis of X-ray Patterns in Infection and Tumor

May 10, 2021/in Vol 7 | Issue 2 | May-Aug 2021 /by jbstadmin

Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

May 10, 2021/in Vol 7 | Issue 2 | May-Aug 2021 /by jbstadmin

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Analysis of X-ray Patterns in Infection and Tumor

May 10, 2021/in Vol 7 | Issue 2 | May-Aug 2021 /by jbstadmin

Author: Dominic Puthoor[1]

[1]Department of Orthopaedic Oncologist, Amala Institute of Medical Sciences, Thrissur, Kerala, India.

Address of Correspondence
Dr. Dominic Puthoori,
Department of Orthopaedic Oncologist, Amala Institute of Medical Sciences, Thrissur, Kerala, India.
E-mail: dkputhur@gmail.com

Abstract

Introduction: In diagnosis of bone tumor, X-ray is as important, if not more important than pathology report. However, X-ray had specific disadvantage. Tumor mimics especially infection can have same appearance as tumor in the X-ray. In this article, author analyzes the different patterns of X-ray changes common to tumor and infection and points outs that X-ray depicts the aggressiveness of the condition rather than a specific diagnosis.

Keywords: X-ray, Bone tumor, Tumor mimics.

References:
1. Mandal AK, Chaudhary S. Text Book of Pathology. Synapse Books. 1st ed. New Delhi, India: Avichal Publishing Company; 2010. p. 51, 113.
2. Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran Pathological Basis of Diseases. Amsterdam, Netherlands: Elsevier; 2010. p. 1205-35.
3. Enneking WF, Bertoni F, The staging system for benign and malignant tumours of the musculoskeletal system. In: Nadarajan M, editors. Article Written in Principles of Orthopedic Oncology; 1997. p. 112-20.
4. Shimose S, Sugita T, Kubo T, Matsuo T, Nobuto H, Ochi M. Differential diagnosis between osteomyelitis and bone tumors. Acta Radiol 2008;49:928-33.
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7. Puthur D. X-ray patterns common to infection and tumours. Kerala J Orthop 2014;27:73-7.
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How to Cite this article: Puthoor D | Analysis of X-ray patterns in infection and tumor. | Journal of Bone and Soft Tissue Tumors | May-August 2021; 7(2): 5-8.

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Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

May 10, 2021/in Vol 7 | Issue 2 | May-Aug 2021 /by jbstadmin

DOI:10.13107/jbst.2021.v07i02.46

Author: Abigail R. Tud[1], Cesar D. Dimayuga[1]

[1]Department of Orthopedics, The Medical City, Ortigas Avenue, Pasig City, Philippines 1605.

Address of Correspondence
Dr. Abigail R. Tud,
Musculoskeletal Tumor Unit, Philippine Orthopedic Center, Banawe corner Maria Clara Streets, Santa Mesa Heights, Quezon City, Metro Manila, Philippines 1114.
E-mail: abitud@gmail.com

Abstract

Introduction: Fibrous dysplasia (FD) is a benign lesion characterized by replacement of normal bone with abnormal connective tissue. It occurs in monostotic or polyostotic forms, with a rare but proven potential for malignant transformation. Symptoms of acute pain, rapid swelling, or an enlarging mass should increase suspicion for possible sarcomatous change. Complete surgical resection is the mainstay of treatment, and chemotherapy is recommended to improve survival.
Case Report: A 52-year-old male presented with a painful, enlarging mass on the right proximal thigh 2 years after undergoing plate fixation of the distal femur for a pathologic fracture secondary to monostotic FD. Diagnostic imaging revealed signs of recurrence, and core needle biopsy revealed aggressive features suggestive of malignant transformation. Following surgical resection and chemotherapy, the outcome has been uneventful without evidence of recurrence or metastasis at 4-year post-operation.
Conclusion: Malignant transformation in monostotic FD is rare. Symptom exacerbation should increase the suspicion for sarcomatous change and prompt the need for diagnostic imaging as well as histologic confirmation.
Keywords: Fibrosarcoma, fibrous dysplasia, malignant transformation, secondary sarcoma.

References:
1. Picci P, Sieberova G, Alberghini M, Balladelli A, Vanel D, Hogendoorn PC, et al. Late sarcoma development after curettage and bone grafting of benign bone tumors. Eur J Radiol 2011;77:19-25.
2. Muthusamy S, Conway SA, Subhaeong TY, Temple HT. Locally aggressive fibrous dysplasia mimicking malignancy: A report of four cases and review of the literature. Clin Orthop Relat Res 2015;473:742-50.
3. Qu N, Yao W, Cui X, Zhang H. Malignant transformation in monostotic fibrous dysplasia: Clinical features, imaging features, outcomes in 10 patients, and review. Medicine (Baltimore) 2015;94:e369.
4. Mardekian SK, Tuluc M. Malignant sarcomatous transformation of fibrous dysplasia. Head Neck Pathol 2015;9:100-3.
5. Riddle ND, Bui MM. Fibrous dysplasia. Arch Pathol Lab Med 2013;137:8-21.
6. Ruggieri P, Sim FH, Bond JR, Unni KK. Malignancies in fibrous dysplasia. Cancer 1994;73:1411-24.
7. Chapurlat RD, Gensburger D, Jimenez-Andrade JM, Ghilardi JR, Kelly M, Mantyh P. Pathophysiology and medical treatment of pain in fibrous dysplasia of bone. Orphanet J Rare Dis 2012;7:S3.
8. Doqanavsarqil B, Argin M, Kececi B, Sezak M, Sanli UA, Oztop F. Secondary osteosarcoma arising in fibrous dysplasia, case report. Arch Orthop Trauma Surg 2009;129:439-44.
9. Stanton RP, Ippolito E, Springfield D, Lindaman L, Wientroub S, Leet A. The surgical management of fibrous dysplasia of bone. Orphanet J Rare Dis 2012;7 Suppl 1:S1.
10. Hatano H, Morita T, Arllzumi T, Kawashima H, Ogose A. Malignant transformation of fibrous dysplasia: A case report. Oncol Lett 2014;8:384-6.
11. National Comprehensive Cancer Network (NCCN). Bone Cancer, NCCN Guidelines; 2013. Available from: http://www.nccn.org. [Last accessed on 2016 Mar 16].

How to Cite this article: Tud AR, Dimayuga CD| Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report | Journal of Bone and Soft Tissue Tumors | May-Aug 2021; 7(2): 1-4.

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Analysis of X-ray Patterns in Infection and Tumor

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Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

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Analysis of X-ray Patterns in Infection and Tumor

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Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

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