Blog Elements

Half Sized Blog Element (Single Author Style)

Half Sized Blog Element (Multi Author Style)

Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

May 10, 2021

Case Report | Volume 7 | Issue 2 | JBST May- August 2021 | Page 1-4 | Abigail R. Tud, Cesar D. Dimayuga. DOI:10.13107/jbst.2021.v07i02.46 Author: Abigail R. Tud[1], Cesar D. Dimayuga[1] [1]Department of Orthopedics, The Medical City, Ortigas Avenue, Pasig City, Philippines 1605. Address of Correspondence Dr. Abigail R. Tud, Musculoskeletal Tumor Unit, Philippine Orthopedic […]

Submit Article

March 26, 2021

Submit Manuscript Currently, JBST is accepting submissions only by its article submission System “Scripture” For more Information regarding SCRIPTURE – Click Heregmail account create Already have a Username/Password for Scripture? GO TO LOGIN Need a Username/Password for Scripture? GO TO REGISTRATION Registration and login to SCRIPTURE is required to submit articles to the Journal of Bone and Soft Tissue […]

Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

May 10, 2021

Submit Article

March 26, 2021

Full Sized Blog Element (Big Preview Pic)

Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

May 10, 2021

DOI:10.13107/jbst.2021.v07i02.46

Author: Abigail R. Tud[1], Cesar D. Dimayuga[1]

[1]Department of Orthopedics, The Medical City, Ortigas Avenue, Pasig City, Philippines 1605.

Address of Correspondence
Dr. Abigail R. Tud,
Musculoskeletal Tumor Unit, Philippine Orthopedic Center, Banawe corner Maria Clara Streets, Santa Mesa Heights, Quezon City, Metro Manila, Philippines 1114.
E-mail: abitud@gmail.com

Abstract

Introduction: Fibrous dysplasia (FD) is a benign lesion characterized by replacement of normal bone with abnormal connective tissue. It occurs in monostotic or polyostotic forms, with a rare but proven potential for malignant transformation. Symptoms of acute pain, rapid swelling, or an enlarging mass should increase suspicion for possible sarcomatous change. Complete surgical resection is the mainstay of treatment, and chemotherapy is recommended to improve survival.
Case Report: A 52-year-old male presented with a painful, enlarging mass on the right proximal thigh 2 years after undergoing plate fixation of the distal femur for a pathologic fracture secondary to monostotic FD. Diagnostic imaging revealed signs of recurrence, and core needle biopsy revealed aggressive features suggestive of malignant transformation. Following surgical resection and chemotherapy, the outcome has been uneventful without evidence of recurrence or metastasis at 4-year post-operation.
Conclusion: Malignant transformation in monostotic FD is rare. Symptom exacerbation should increase the suspicion for sarcomatous change and prompt the need for diagnostic imaging as well as histologic confirmation.
Keywords: Fibrosarcoma, fibrous dysplasia, malignant transformation, secondary sarcoma.

References:
1. Picci P, Sieberova G, Alberghini M, Balladelli A, Vanel D, Hogendoorn PC, et al. Late sarcoma development after curettage and bone grafting of benign bone tumors. Eur J Radiol 2011;77:19-25.
2. Muthusamy S, Conway SA, Subhaeong TY, Temple HT. Locally aggressive fibrous dysplasia mimicking malignancy: A report of four cases and review of the literature. Clin Orthop Relat Res 2015;473:742-50.
3. Qu N, Yao W, Cui X, Zhang H. Malignant transformation in monostotic fibrous dysplasia: Clinical features, imaging features, outcomes in 10 patients, and review. Medicine (Baltimore) 2015;94:e369.
4. Mardekian SK, Tuluc M. Malignant sarcomatous transformation of fibrous dysplasia. Head Neck Pathol 2015;9:100-3.
5. Riddle ND, Bui MM. Fibrous dysplasia. Arch Pathol Lab Med 2013;137:8-21.
6. Ruggieri P, Sim FH, Bond JR, Unni KK. Malignancies in fibrous dysplasia. Cancer 1994;73:1411-24.
7. Chapurlat RD, Gensburger D, Jimenez-Andrade JM, Ghilardi JR, Kelly M, Mantyh P. Pathophysiology and medical treatment of pain in fibrous dysplasia of bone. Orphanet J Rare Dis 2012;7:S3.
8. Doqanavsarqil B, Argin M, Kececi B, Sezak M, Sanli UA, Oztop F. Secondary osteosarcoma arising in fibrous dysplasia, case report. Arch Orthop Trauma Surg 2009;129:439-44.
9. Stanton RP, Ippolito E, Springfield D, Lindaman L, Wientroub S, Leet A. The surgical management of fibrous dysplasia of bone. Orphanet J Rare Dis 2012;7 Suppl 1:S1.
10. Hatano H, Morita T, Arllzumi T, Kawashima H, Ogose A. Malignant transformation of fibrous dysplasia: A case report. Oncol Lett 2014;8:384-6.
11. National Comprehensive Cancer Network (NCCN). Bone Cancer, NCCN Guidelines; 2013. Available from: http://www.nccn.org. [Last accessed on 2016 Mar 16].

How to Cite this article: Tud AR, Dimayuga CD| Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report | Journal of Bone and Soft Tissue Tumors | May-Aug 2021; 7(2): 1-4.

[Full Text HTML] [Full Text PDF] [XML]

Submit Article

March 26, 2021

Submit Manuscript

Currently, JBST is accepting submissions only by its article submission System “Scripture”

For more Information regarding SCRIPTURE – Click Here gmail account create

Already have a Username/Password for Scripture?
GO TO LOGIN

Need a Username/Password for Scripture?
GO TO REGISTRATION

Registration and login to SCRIPTURE is required to submit articles to the Journal of Bone and Soft Tissue Tumors and to check the status of current submissions.

In case of any Queries regarding SCRIPTURE, please write to us at editor.jbst@gmail.com

Format all articles according to Journal Guidelines: Click here for Journal Guidelines

Conflict of Interest forms: Download Here

(Conflict of Interest form– COI is a special document. we can’t open it on the browser. To download the form click on the link provided and use the option as seen in the above picture )

Conflict of Interest forms are according to Guidelines by the International Committee of Medical Journal Editors and Each Authors details have to be filled separately and submitted with the manuscript. Plagiarism is not permitted and Journal will check every article for plagiarism using ‘Plagtracker’ and google search.

Article submission Charges: None

Article Publishing charges: 5000 INR or 150 $ (for international article). The publishing charges have to be paid only on acceptance of the article]

JBST will maintain the open access policy and will continue to run with contribution from authors and donations from IORG

Half Sized Blog Element (Single Author Style)

Half Sized Blog Element (Multi Author Style)

Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

Like this:

Submit Article

Like this:

Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

Like this:

Submit Article

Like this:

Full Sized Blog Element (Big Preview Pic)

Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

[Full Text HTML] [Full Text PDF] [XML]

Like this:

Submit Article

Submit Manuscript

Like this:

Like this:

Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

Important Information

Journal of Bone and Soft Tissue Tumors (JBST) License

Half Sized Blog Element (Single Author Style)

Half Sized Blog Element (Multi Author Style)

Like this:

Like this:

Like this:

Like this:

Full Sized Blog Element (Big Preview Pic)

[Full Text HTML] [Full Text PDF] [XML]

Like this:

Submit Manuscript

Like this:

Share this:

Like this:

Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

Important Information

Journal of Bone and Soft Tissue Tumors (JBST) License