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Histopathology of Giant-cell Tumor of Bone – Current Concept

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | Page 2-5| Sanjeev Shah. Authors: Sanjeev Shah [1]. [1] Department of Pathology, Unipath Laboratory Specialty Ltd, Beside JMC House, Ahmedabad, Gujarat, India. Address of Correspondence Dr. Sanjeev Shah, 102, First floor, Sanoma Plaza, Opp. Parimal Garden, Beside JMC House, Ellisbridge, Ahmedabad – 380006, Gujarat, India. E-mail: […]

Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | Page 6-9 | Shekhar Kumta, Carol Lau, K C Wong. Authors: Shekhar Kumta [1], Carol Lau [1], K C Wong [2]. [1] Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, [2] Department of Orthopaedics& Traumatology, The Prince of Wales Hospital, Hong […]

Histopathology of Giant-cell Tumor of Bone – Current Concept

September 10, 2017

Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

September 10, 2017

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Histopathology of Giant-cell Tumor of Bone – Current Concept

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | Page 2-5| Sanjeev Shah.

Authors: Sanjeev Shah [1].

[1] Department of Pathology, Unipath Laboratory Specialty Ltd, Beside JMC House, Ahmedabad, Gujarat, India.

Address of Correspondence
Dr. Sanjeev Shah,
102, First floor, Sanoma Plaza, Opp. Parimal Garden, Beside JMC House, Ellisbridge, Ahmedabad – 380006, Gujarat, India.
E-mail: dcp72002@yahoo.com

Abstract

GCTB is a primary osteolytic bone tumor which can recurrence, undergo metastasis, and malignant transformation. Current understanding of molecular pathogenesis of GCTB particularly RANK on osteoclast-like GCs and RANKL on stromal cells and development of newer agents such as denosumab and INF-α has tremendously impacted management of patients with GCTB.
Keywords: Giant-cell tumor of bone histopathology, current concept.

References

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How to Cite this article: Shah S. Histopathology of Giant-cell Tumor of Bone – Current Concept. Journal of Bone and Soft Tissue Tumors Sep-Dec 2017;3(2): 2-5.

(Abstract Full Text HTML) (Download PDF)

Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

September 10, 2017

Vol 3 | Issue 2 | Sep-Dec 2017 | Page 6-9 | Shekhar Kumta, Carol Lau, K C Wong.

Authors: Shekhar Kumta [1], Carol Lau [1], K C Wong [2].

[1] Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong,
[2] Department of Orthopaedics& Traumatology, The Prince of Wales Hospital, Hong Kong.

Address of Correspondence
Dr. Shekhar Kumta,
103-E, Learning Resource Centre, Block A, Prince of Wales Hospital, Shatin, Hong Kong.
Email: shekharkumta@gmail.com

Abstract

GCT of bone is a locally aggressive bone-destroying tumor. The primary neoplastic tumor cell is a RANKL over expressing cell that drives osteoclast recruitment and activation, ultimately leading to bone resorption at the site of the lesion. Osteoclast driven destruction in GCT may be ameliorated with the use of drugs such as Bisphophonates, which target Osteoclasts as well as the primary neoplastic stromal cells. Denusomab, is a monoclonal antibody against RANKL and it has a dramatic effect on Osteoclasts. Adjuvant therapies have reduced recurrence rates in GCT of bone, but uncertainties remain as to the optimum dose-intensity of the drugs and the duration of treatment.
Keywords: Tumor, bone destruction, Giant Cell Tumor of Bone.

References

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How to Cite this article: Kumta S, Lau C, Wong K C. Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice. Journal of Bone and Soft Tissue Tumors Sep-Dec 2017;3(2): 6-9..

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Histopathology of Giant-cell Tumor of Bone – Current Concept

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Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

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Histopathology of Giant-cell Tumor of Bone – Current Concept

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Histopathology of Giant-cell Tumor of Bone – Current Concept

Authors: Sanjeev Shah [1].

Abstract

References

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Systemic Adjuvant Therapies in the Management of Giant Cell Tumor of Bone: Current State of Understanding and Practice

Authors: Shekhar Kumta [1], Carol Lau [1], K C Wong [2].

Abstract

References

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Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

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Authors: Sanjeev Shah [1].

Abstract

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Authors: Shekhar Kumta [1], Carol Lau [1], K C Wong [2].

Abstract

References

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Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

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Journal of Bone and Soft Tissue Tumors (JBST) License