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Journal of Bone and Soft Tissue Tumors: A New Beginning

May 10, 2015

Vol 1 | Issue 1 | May – August 2015 | page:1-2 | Dr. Yogesh Panchwagh & Dr. Ashok Shyam. Author: Dr. Yogesh Panchwagh [1], Dr. Ashok Shyam [2,3]. [1]Orthopaedic Oncology Clinic, Pune, India. [2] Indian Orthopaedic Research Group, Thane, India [3] Sancheti Institute for Orthopaedics &Rehabilitation, Pune, India Address of Correspondence Dr. Yogesh Panchwagh. Orthopaedic […]

OncoMedia Journal of Bone and Soft Tissue Tumors (JBST) May-August 2015

May 10, 2015

Vol 1 | Issue 1 | May – August 2015 | page:51-52 | Dr Ashish Gulia[1], Dr Ashok Shyam[2,3]. Author: Dr Ashish Gulia [1], Dr Ashok Shyam [2,3]. Dr. Ashish Gulia MS (Ortho), Mch – Surgical Oncology [1]Fellowship – Musculoskeletal Oncology (TMH – HBNI) Asst. Professor – Orthopaedic Oncology, Tata Memorial Hospital, Mumbai, India. Dr Ashok […]

Journal of Bone and Soft Tissue Tumors: A New Beginning

May 10, 2015

OncoMedia Journal of Bone and Soft Tissue Tumors (JBST) May-August 2015

May 10, 2015

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Journal of Bone and Soft Tissue Tumors: A New Beginning

May 10, 2015

Vol 1 | Issue 1 | May – August 2015 | page:1-2 | Dr. Yogesh Panchwagh & Dr. Ashok Shyam.

Author: Dr. Yogesh Panchwagh [1], Dr. Ashok Shyam [2,3].

[1]Orthopaedic Oncology Clinic, Pune, India.
[2] Indian Orthopaedic Research Group, Thane, India
[3] Sancheti Institute for Orthopaedics &Rehabilitation, Pune, India

Address of Correspondence
Dr. Yogesh Panchwagh.
Orthopaedic Oncology Clinic, 101, Vasanth plot 29, Bharat Kunj Society -2, Erandwana, Pune – 38, India.
Email: drpanchwagh@gmail.com

Editorial: Journal of Bone and Soft Tissue Tumors: A New Beginning

The faculty of bone and soft tissue tumors has seen tremendous growth in terms of recognition and advancement in recent years. As pointed out by Dr Ajay Puri [1] the field is fairly new in India but has shown great promise both in terms of patient care and education. The aspects of education on which the Journal of Bone and Soft Tissue Tumors (JBST) will focus is on inter disciplinary collaborations and providing platform for publication of relevant research and clinical studies from all over the world and specially from Asia. The journal also aims to provide the most relevant and practice based information to everyone involved in care of bone and soft tissue tumors.
Cancers on a whole and bone tumors specifically require multidisciplinary approach towards managing patients. Orthopaedic Oncology as it is termed is not simply a surgical branch but requires inputs from various different faculties including orthopaedic oncologist, radiologist, pathologist, medical oncologist, radiation oncologist, pediatric medical oncologist, surgical oncologist, plastic surgeons and micro-vascular surgeons. In fact the first symposium published in JBST is written by pediatric oncologists, radiation oncologist and orthopaedic oncologist which say a lot about how important this interdisciplinary collaboration is to JBST[2,3,4]. JBST specifically aims to provide a platform where multiple faculties can come together and interact. We have inter disciplinary members on the editorial board and in coming months we will be expanding this further to include many more faculties like biomechanics, genetics, basic sciences and Prosthetics. This will help us understand the viewpoints of each other and also help us provide better patient care.
The other aim of the journal is promotion of research activities and publication of clinically relevant articles not only from the western world but also from Africa and Asia. Although research has been increasingly seen as gaining importance in our country but there exists a lot of research apathy and research lethargy. JBST aims to provide a platform for publication and will also provide assistance in manuscript preparation which will be useful for new researchers and writers. This assistance will be provided through the writers club of the orthopaedic research group which is also involved in conception and publication of the Journal. Thus the authors will be supported at every stage of publication and best quality articles will be made available to readers
The main focus of the Journal will be to provide clinically relevant articles that will be directly applicable to treating patients in real world and not only on paper with statistics. We urge our authors to keep statistics to minimal and to use only basic statistics in their articles and focus on bringing out the clinically relevant points in their articles. The reviewers too are advised to focus on the clinical relevance of the article and on the paradigm in which the particular article will be useful in treating patients. The journal will focus both on Evidence based medicine and on Practice based medicine and will try to find a balance between the two. With this in mind features like expert reviews, narrative reviews will be published along with systematic reviews. Technical notes and case reports, case studies will be regular features and will have specific focus on case based approach to particular clinical scenario.
With these aims we have embarked on a journey toward excellence in treatment of bone and soft tissue tumors. We would like to thank all the editorial board members who encouraged us and helped us in every way to start this venture. We thank all our authors who provided us with excellent articles and lastly we thank our reviewers who did rapid reviews and corrections in the articles. We thank the Orthopaedic Research Group for supporting this venture and helping at every step of the publication process. The future of JBST looks very promising specially with the support from the editorial board. We as a team are committed to JBST and aim to make this journal a landmark publication in years to come.
With this we leave you to enjoy the First issue of the Journal of Bone and Soft Tissue Tumors.

Yogesh Panchwagh & Ashok Shyam

References:

1. Puri A. The “ODYSSEY”: “Orthopaedic Oncology” – My journey thus far! Journal of Bone and Soft Tissue Tumors May- Aug 2015;1(1):3-5
2. Valvi S & Kellie SJ. Ewing Sarcoma: Focus on Medical Management. Journal of Bone and Soft Tissue Tumors May-Aug 2015;1(1):8-17
3. Irukulla MM, Joseph DM. Management of Ewing Sarcoma: Current Management and the Role of Radiation Therapy. Journal of Bone and Soft Tissue Tumors May-Aug 2015;1(1):18-22
4. Panchwagh Y. Ewing Sarcoma: Focus on Surgical Management. Journal of Bone and Soft Tissue Tumors May-Aug 2015;1(1):23-28

How to Cite this article: Panchwagh Y, Shyam AK. Journal of Bone and Soft Tissue Tumors: A New Beginning Journal of Bone and Soft Tissue Tumors May-Aug 2015; 1(1):1-2

: Dr Yogesh Panchwagh

: Dr Ashok Shyam

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OncoMedia Journal of Bone and Soft Tissue Tumors (JBST) May-August 2015

May 10, 2015

Vol 1 | Issue 1 | May – August 2015 | page:51-52 | Dr Ashish Gulia[1], Dr Ashok Shyam[2,3].

Author: Dr Ashish Gulia [1], Dr Ashok Shyam [2,3].

Dr. Ashish Gulia MS (Ortho), Mch – Surgical Oncology
[1]Fellowship – Musculoskeletal Oncology (TMH – HBNI)
Asst. Professor – Orthopaedic Oncology, Tata Memorial Hospital, Mumbai, India.

Dr Ashok Shyam MS (Ortho)
[2]Indian Orthopaedic Research Group, Thane, India.
[3] Sancheti Institute for Orthopaedics &Rehabilitation, Pune, India.

Indian Musculo Skeletal Oncology Society (IMSOS)

Musculoskeletal oncology is a relatively new specialty, both as far as orthopaedics and oncology goes. For sarcoma care to evolve, ideas to surface and multi institute or multi disciplinary collaborations to develop in the fields of basic research, patient care, biomaterials and prosthesis, there is a need for a common platform where all of us involved in the treatment of sarcomas can interact. This would also help foster training and education opportunities, promote dissemination of knowledge and aid in the development of treatment guidelines suitable for our socio cultural environment. As the field of musculoskeletal oncology continues to develop globally and in India, it is time for us to reflect on what is required for it to grow further so that we are able to offer the best care to the maximum number of patients.
The Indian Musculo Skeletal Oncology Society (IMSOS) is a step in this direction. It aims to “promote scientific, evidence based, comprehensive multidisciplinary management of bone and soft tissue sarcomas and encourage basic and clinical research.” In the words of Henry Ford “Coming together is a beginning; keeping together is progress; working together is success”.
The Indian Musculoskeletal Oncology Society 1st Annual Conference was organised on 13th and 14th March, 2015 at the Tata Memorial Hospital, Mumbai.
The theme of the conference was “Cure, control or comfort – In tumors teamwork triumphs!” reflects the ethos of IMSOS of bringing together all specialties interested in sarcoma care to interact on a continuous basis and help further advances in musculoskeletal oncology. The second meeting is planned in Cochin in 2016. Visit www.imsos.org for more information.

Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors

Tissue specificity of tumor cells to metastasize, for example predilection of lung carcinoma to spread to bone, is still poorly understood. It is believe that the tumor cells with seed into tissues that act as good soil form them to grow. In this respect bone marrow is said to be the metastatic niche for seeding and growth of variety of tumors. The tumor cells mimic the homeopoetic stem cells and capture the niche for themselves through series of complex steps involving cytokines, adhesion molecules and physical factors. The detailed mechnism still eludesus but we do grasp the importance of this phenomenon. This colonisation may play important role in cases that relapse after chemotherapy. In these cases the tumor cells may find safe haven in the bone marrow niche and can emerge later to cause further metastasis and disease spread. Understanding of these mechanism will help in developing effective chemotherapeutic solutions and may allow to restrict the disease for spreading too. Recent article published in BoneKey1 elaborates on the function of metastatic niche and provides insight into new developments to tackle this. But we are still far away from any clinical implication of the theory.
1. Shiozawa Y, Eber MR, Berry JE, Taichman RS. Bone marrow as a metastatic niche
For disseminated tumor cells from solid tumors. Bonekey Rep. 2015 May 20;4:689Osteoclasts cause muscle weakness and bone pain in bone tumorsOsteoclasts cause muscle weakness and bone pain in bone tumors.

Osteoclasts cause muscle weakness and bone pain in bone tumors

Understanding the basic mechanisms by which tumors cause certain systemic symptoms will help in understanding and planning therapeutic strategies. Tumor cells stimulate osteoclastic activity which lead to outpour of excess of bone derived growth factor. The bone derived growth factors have direct effect on the muscles and cause muscle weakness as well as muscle wasting. It is believed that in this muscle-bone synergy it’s the muscle that is a more powerful secretary gland and has strong influence on bone homeostasis. However in cases with bone tumor this relationship is reversed and also distorted leading to muscle wasting. Most important factor is TGF-beta family of ‘osteokines’. These may cause reduction is both muscle mass as well as muscle function. The weak bones add to the impaired function. The same hyperactive osteoblasts create an acidic environment in the bone which is directly related to severity of bone pains. Two good article clear a lot of confusion and provide fresh insights into the subject[1,2].

1. Waning DL, Guise TA. Cancer-associated muscle weakness: What’s bone got to do
with it? Bonekey Rep. 2015 May 20;4:691.
2.Nagae M, Hiraga T, Yoneda T. Acidic microenvironment created by osteoclasts
Causes bone pain associated with tumor colonization. J Bone Miner Metab. 2007;25(2):99-104.

Hair Bucket Challenge’ helping Sherwood boy with Ewing’s Sarcoma

Social impact of bone tumors are not unknown but this is unique. We all know about the ice bucket challenge, but an hair bucket challenge is unheard of. This was created for fourth-grader Tony Budesilich, who was recently diagnosed with Ewing sarcoma, a rare bone cancer in his leg (fibula which was surgically excised. The boy underwent seven rounds of chemotherapy and started losing hair. His friends noticed this change specifically Aidan Cook (12 yrs) who shaved his head and thus started a challenge the other boys to shave theirhead. This became an internet sensation and lot of kids [not only friends of Tony] from the locality participated and we could see a lot of shaved head in Sherwoods.
Tony has been given a good prognosis but has to continue the complete course of chemotherapy, but he definitely feels great about how his friends and family have supported him in a very difficult phase of his life

Read more: http://www.kptv.com/story/29109392/hair-bucket-challenge-helping-sherwood-boy-with-rare-bone-cancer#ixzz3d8e4tHuP.

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Join the OncoMedia Team and keep the interesting news coming through. We invite trainees of all faculties involved in the care of bone and soft tissue tumors to become a part of this active and dynamic team. They will be required to search the web and find interesting news and facts (which we will otherwise miss) and send it to the editorial board. A short original write-up will be necessary for the same. If accepted your news article will be published with your photograph and affiliation. To be a part of OncoMedia please write an email to us at editor.jbst@gmail.com

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Journal of Bone and Soft Tissue Tumors: A New Beginning

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OncoMedia Journal of Bone and Soft Tissue Tumors (JBST) May-August 2015

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Journal of Bone and Soft Tissue Tumors: A New Beginning

Author: Dr. Yogesh Panchwagh [1], Dr. Ashok Shyam [2,3].

Editorial: Journal of Bone and Soft Tissue Tumors: A New Beginning

References:

(Abstract) (Full Text HTML) (Download PDF)

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OncoMedia Journal of Bone and Soft Tissue Tumors (JBST) May-August 2015

Author: Dr Ashish Gulia [1], Dr Ashok Shyam [2,3].

Indian Musculo Skeletal Oncology Society (IMSOS)

Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors

Osteoclasts cause muscle weakness and bone pain in bone tumors

Hair Bucket Challenge’ helping Sherwood boy with Ewing’s Sarcoma

(Abstract) (Full Text HTML) (Download PDF)

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Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

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Author: Dr. Yogesh Panchwagh [1], Dr. Ashok Shyam [2,3].

Editorial: Journal of Bone and Soft Tissue Tumors: A New Beginning

References:

(Abstract) (Full Text HTML) (Download PDF)

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Author: Dr Ashish Gulia [1], Dr Ashok Shyam [2,3].

Indian Musculo Skeletal Oncology Society (IMSOS)

Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors

Osteoclasts cause muscle weakness and bone pain in bone tumors

Hair Bucket Challenge’ helping Sherwood boy with Ewing’s Sarcoma

(Abstract) (Full Text HTML) (Download PDF)

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Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

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Journal of Bone and Soft Tissue Tumors (JBST) License