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Biphasic synovial sarcoma – A ten year experience with molecular profile and clinical outcome

July 10, 2018

Vol 4 | Issue 2 | July-Dec 2018 | Page 14-19 | Kala Gnanasekaran Kiruthiga, Anne Jennifer Prabhu, Rekha Pai, Sramana Mukhopadhyay, Reka.K, V.T.K.Titus, Selvamani Backianathan. Authors: Kala Gnanasekaran Kiruthiga [1], Anne Jennifer Prabhu [1], Rekha Pai [1], Sramana Mukhopadhyay [1], Reka.K [2], V.T.K.Titus [3], Selvamani Backianathan [4]. [1] Department of Pathology, Christian Medical College, […]

Osteosarcoma of Extragnathic Skull Bones-clinicopathological Profile of Eight Cases

July 10, 2018

Vol 4 | Issue 2 | July-Dec 2018 | Page 11-13 | Mahfooz Basha Mohamed, Jayasree Kattoor, Kusumakumary Parukuttyamma, Geetha Narayanan, Anitha Mathews, Thara Somanathan. Authors: Mahfooz Basha Mohamed [1], Jayasree Kattoor [2], Kusumakumary Parukuttyamma [3], Geetha Narayanan [4], Anitha Mathews [2], Thara Somanathan [2]. [1] Department of Laboratory Medicine, GKNM Hospital, Coimbatore 641006, Tamil […]

Biphasic synovial sarcoma – A ten year experience with molecular profile and clinical outcome

July 10, 2018

Osteosarcoma of Extragnathic Skull Bones-clinicopathological Profile of Eight Cases

July 10, 2018

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Biphasic synovial sarcoma – A ten year experience with molecular profile and clinical outcome

July 10, 2018

Vol 4 | Issue 2 | July-Dec 2018 | Page 14-19 | Kala Gnanasekaran Kiruthiga, Anne Jennifer Prabhu, Rekha Pai, Sramana Mukhopadhyay, Reka.K, V.T.K.Titus, Selvamani Backianathan.

Authors: Kala Gnanasekaran Kiruthiga [1], Anne Jennifer Prabhu [1], Rekha Pai [1], Sramana Mukhopadhyay [1], Reka.K [2], V.T.K.Titus [3], Selvamani Backianathan [4].

[1] Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
[2] Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.
[3] Department of Orthopaedics, Christian Medical College, Vellore, Tamil Nadu, India.
[4] Department of Radiotherapy, Christian Medical College, Vellore, Tamil Nadu, India.

Address of Correspondence
Dr. Anne Jennifer Prabhu,
Address: Department of Pathology, ASHA Building, Christian Medical College, Vellore, Tamil Nadu, India.
E-mail: annejennifer91@gmail.com

Abstract

Context: Synovial sarcoma is one of the commonly encountered spindle cell sarcomas of soft tissue. However, Biphasic synovial sarcoma (BSS) is a rare subtype of synovial sarcoma with limited literature on clinical profile, molecular characteristics and survival outcome.
Aims: We propose to describe the immuno – morphology, clinical features, molecular profile and outcome of patients with BSS.
Settings and Design: This retrospective study included 13 cases of BSS, 3.2% of all synovial sarcomas diagnosed over 10 years in our institute. The clinico-pathological features were studied in detail and immunohistochemistry for TLE-1, EMA, CD34, CD99 and S100 was done. Real time PCR and DNA sequencing for the common translocations (SYT-SSX1/ SYT-SSX2) were performed.
Statistical analysis used: Statistical Package for Social Services (SPSS) software Version 21.0 (Armonk, NY: IBM Corp).
Results: BSS was most commonly seen in young, the most common site being soft tissue of extremities (92.3%). 53.8% of patients presented at Enneking stage IIB. The FNCLCC grade varied between 2(46.2%) and 3(53.8%). All cases were positive for EMA and TLE-1; negative for CD34 and S100. Ten of the eleven (90.9%) patients tested had SYT-SSX1 translocation. Over a period of 8 to 46 months, 53.8% cases were alive and well with no evidence of disease; three had (30%) recurred, one (10%) had lung metastasis and one (10%) died.
Conclusions: BSS is most common in extremities. The immunohistochemical profile matches that of monophasic synovial sarcoma. FNCLCC grade is 2 to 3; however the grade does not correlate with clinical outcome. Most cases show SYT-SSX1 translocation. 53.8% cases were alive and well after a mean follow up of 20 months.
Keywords: Biphasic, follow-up, immunoprofile, SYT-SSX1, synovial sarcoma.
Keyword: Biphasic synovial sarcoma has the same immunoprofile as the monophasic subtype. All patients who tested positive had SYT-SSX1 translocation. More than 50% of patients were alive and well after 20 months.

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How to Cite this article: Kiruthiga KG, Anne Jennifer P, Rekha P, Sramana M, Reka.K, V.T.K.Titus, Selvamani B.. Biphasic synovial sarcoma – A ten year experience with molecular profile and clinical outcome. Journal of Bone and Soft Tissue Tumors July-Dec 2018;4(2): 14-19.

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Osteosarcoma of Extragnathic Skull Bones-clinicopathological Profile of Eight Cases

July 10, 2018

Vol 4 | Issue 2 | July-Dec 2018 | Page 11-13 | Mahfooz Basha Mohamed, Jayasree Kattoor, Kusumakumary Parukuttyamma, Geetha Narayanan, Anitha Mathews, Thara Somanathan.

Authors: Mahfooz Basha Mohamed [1], Jayasree Kattoor [2], Kusumakumary Parukuttyamma [3], Geetha Narayanan [4], Anitha Mathews [2], Thara Somanathan [2].

[1] Department of Laboratory Medicine, GKNM Hospital, Coimbatore 641006, Tamil Nadu, India.
[2] Department of Pathology, Regional Cancer Centre, Trivandrum 695011, Kerala, India.
[3] Department of Paediatric Oncology, Regional Cancer Centre, Trivandrum 695011, Kerala, India.
[4] Department of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, Kerala.

Address of Correspondence
Dr. JayasreeKattoor,
Department of Pathology, Regional Cancer Centre, Trivandrum-695011, Kerala, India.
Email: jayasreeramdas@gmail.com

Abstract

Osteosarcoma is the most common primary malignant tumor of bone, usually arising from the metaphysis of the long bones around the knee joint. In 6-13% cases they are located in the head and neck region, of which maxilla and mandible are the most common sites. Osteosarcoma involving the extra-gnathic craniofacial bones account for less than 2% cases. We report eight such cases of osteosarcoma involving this unusual location in the last three years (2011 -2014) and present their clinicopathological profile. Seven patients were under 15 years of age and one patient was 37 years old. Out of the eight cases, four were males and four were females. The location of the tumor included occipital bone, parietal bone, external auditory canal, nasal bone and mastoid. Two patients presented as multicenteric disease with multiple lesions in the skull and elsewhere. Two patients succumbed to the disease while five patients are on follow up. One patient was lost to follow up.A complete en-bloc dissection of the tumor with free margins is a challenge for the operating surgeons. Radiologically they can simulate non-neoplastic lesions or benign tumors as well.These tumors pose a unique therapeutic challenge owing to their unusual location and require a multidisciplinary team approach for management of the patient.
Keywords: Extragnathic, skull, bone, osteosarcoma.

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How to Cite this article: Mohamed MB, Kattoor J, Parukuttyamma K, Narayanan G, Mathews A, Somanathan T. Osteosarcoma of Extragnathic Skull Bones-clinicopathological Profile of Eight Cases. Journal of Bone and Soft Tissue Tumors July-Dec 2018;4(2): 11-13.

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Biphasic synovial sarcoma – A ten year experience with molecular profile and clinical outcome

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Osteosarcoma of Extragnathic Skull Bones-clinicopathological Profile of Eight Cases

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Biphasic synovial sarcoma – A ten year experience with molecular profile and clinical outcome

Authors: Kala Gnanasekaran Kiruthiga [1], Anne Jennifer Prabhu [1], Rekha Pai [1], Sramana Mukhopadhyay [1], Reka.K [2], V.T.K.Titus [3], Selvamani Backianathan [4].

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Osteosarcoma of Extragnathic Skull Bones-clinicopathological Profile of Eight Cases

Authors: Mahfooz Basha Mohamed [1], Jayasree Kattoor [2], Kusumakumary Parukuttyamma [3], Geetha Narayanan [4], Anitha Mathews [2], Thara Somanathan [2].

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Authors: Kala Gnanasekaran Kiruthiga [1], Anne Jennifer Prabhu [1], Rekha Pai [1], Sramana Mukhopadhyay [1], Reka.K [2], V.T.K.Titus [3], Selvamani Backianathan [4].

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Authors: Mahfooz Basha Mohamed [1], Jayasree Kattoor [2], Kusumakumary Parukuttyamma [3], Geetha Narayanan [4], Anitha Mathews [2], Thara Somanathan [2].

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