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Pathologic Fractures Secondary to Primary Non-Hodgkin’s Lymphoma of Bone: A Report of Two Cases Treated with Surgery

December 31, 2021

Case Report | Volume 7 | Issue 3 | JBST September – December 2021 | Page 16-19 | Abigail R Tud, Celestine Marie G Trinidad. DOI:0.13107/jbst.2021.v07i03.61 Author: Abigail R Tud [1], Celestine Marie G Trinidad [2] [1] Musculoskeletal Tumor Unit, Philippine Orthopedic Center, Quezon City, Manila, Philippines. [2] Department of Pathology, Philippine Orthopedic Center, Quezon […]

AI in Logistics and Supply Chain Management Market Report 2026

July 14, 2021

Weighing this many data points while accounting for the many variables involved is nearly impossible for human cognitive functions. AI can assess demand in future supply chains and simulate anomaly events that could disrupt operations. If logistics and supply chains are to support these business process transformations, AI adoption becomes essential. Underpinning a large portion […]

Pathologic Fractures Secondary to Primary Non-Hodgkin’s Lymphoma of Bone: A Report of Two Cases Treated with Surgery

December 31, 2021

AI in Logistics and Supply Chain Management Market Report 2026

July 14, 2021

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Pathologic Fractures Secondary to Primary Non-Hodgkin’s Lymphoma of Bone: A Report of Two Cases Treated with Surgery

December 31, 2021

Author: Abigail R Tud [1], Celestine Marie G Trinidad [2]

[1] Musculoskeletal Tumor Unit, Philippine Orthopedic Center, Quezon City, Manila, Philippines.

[2] Department of Pathology, Philippine Orthopedic Center, Quezon City, Manila, Philippines.

Address of Correspondence
Dr. Abigail R Tud,
Musculoskeletal Tumor Unit, Philippine Orthopedic Center, Quezon City, Manila, Philippines.
E-mail: abitud.pocmtu@gmail.com

Abstract

Background: Primary lymphoma of bone (PLB) is a rare condition accounting for <2% of lymphomas among adults. Diagnosis is confirmed through clinical features, radiologic findings, and immunohistochemical studies. Treatment consists primarily of chemotherapy and radiotherapy. A lack of consensus remains, however, regarding the role of surgery on prognosis. Interventions with potential to improve quality of life therefore warrant further investigation. The authors report two cases of PLB treated with surgery, with favorable outcomes.
Case Presentation 1: A 21-year-old female presented with the left knee pain unaccompanied by constitutional symptoms. Imaging studies showed an isolated pathologic fracture of the left proximal tibia. Histopathology showed an atypical proliferation of large round cells, which stained diffusely and strongly positive for CD20. 90% of the cells also stained positive for the proliferation marker Ki-67. These findings were consistent with a high-grade B-Cell non-Hodgkin’s lymphoma (NHL). The tibial lesion was managed with direct fracture reduction and knee arthrodesis. Six cycles of chemotherapy were completed. Current Musculoskeletal Tumor Society (MSTS) score is 28/30, without evidence of recurrence 3 years post-surgery.
Case Presentation 2: A 69-year-old male sustained a pathologic subtrochanteric fracture after falling on his left hip. Diagnostic imaging revealed no other osseous lesions. Biopsy specimens showed a proliferation of atypical lymphoid cells, and on immunohistochemistry, these were diffusely and strongly positive for lymphocyte common antigen (CD45) and CD20. This was consistent with a high-grade B-Cell NHL. After proximal femoral nailing was performed, no further treatment was given. The patient is currently 2 years post-surgery with MSTS score of 28/30, and no signs of recurrence or metastases.

Conclusion: Current approach to treatment of PLB is multi-modal, but guidelines for surgical intervention are unavailable. Few reports have been made on outcomes after surgery. Pathologic fracture fixation is an option among select patients, affording satisfactory functional outcomes while minimizing morbidity.

Keywords: Knee resection arthrodesis, Non-Hodgkin’s lymphoma of bone, pathologic fracture, primary lymphoma of bone.

References:

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2. Tsoucalas G, Papaioannou TG, Mainta I, Thomaidis V, Fiska A. A rare case of a non-Hodgkin’s lymphoma presented as a single bone lesion. Biomed J Sci Tech Res 2018;3:1-3.
3. Singh T, Satheesh CT, Lakshmaiah KC, Suresh TM, Babu GK, Lokanatha D, et al. Primary bone lymphoma: A report of two cases and review of the literature. J Can Res Ther 2010;6:296-8.
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7. Kitsoulis P, Vlychou M, Papoudou-Bai A, Karatzias G, Charchanti A, Agnantis NJ, et al. Primary lymphomas of bone. Anticancer Res 2006;26:325-38.
8. Mavrogenis AF, Angelini A, Pala E, Zinzani P, Ruggieri P. The role of surgery for haematologic neoplasms of bone. Acta Orthop Belg 2012;78:382-92.
9. Messina C, Christie D, Zucca E, Gospodarowicz M, Ferreri AJ. Primary and secondary bone lymphomas. Cancer Treatment Rev 2015;41:235-46.
10. Bhagavathi S, Fu K. Primary lymphoma of bone: Areview. Semin Diagn Pathol 2014;31:48-52.
11. Bhagavathi S, Micale MA, Les K, Wilson JD, Wiggins ML, Fu K. Primary bone diffuse large B-cell lymphoma. Am J Surg Pathol 2009;33:1463-9.

How to Cite this article: Tud AR, Trinidad CMG | Pathologic fractures secondary to primary non-Hodgkin’s lymphoma of bone: A report of two cases treated with surgery. | Journal of Bone and Soft Tissue Tumors | Sep-Dec 2021; 7(3): 16-19.

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AI in Logistics and Supply Chain Management Market Report 2026

July 14, 2021

AI in logistics

best dealer management systems: Features, integrations, and top fit for your business

The technology enables cleaner transportation options through route optimization that cuts fuel consumption. McKinsey reports that dynamic optimization of routing https://power-at-work.com/lifts-streamlining-logistics-in-high-rise-construction-projects/ and freight contracting reduces both costs and environmental impact. AI provides data analytics for sustainable production, eco-friendly logistics, and greener supply chain practices.

The report, authored by Kearney and presented by Penske Logistics for the Council of Supply Chain Management Professionals, identifies five structural forces that continue to reshape the macro environment.
Resiliency of pharmaceutical supply chains has turned into a board level issue.
Companies must implement controlled data versioning, comply with privacy regulations, and balance cost with accuracy while protecting against malicious data manipulation that could skew AI performance.
AI-driven supply chain planning integrates machine learning, real-time data analytics, and external risk monitoring to anticipate disruptions before they materialize.

Top 11 AIaaS to Enhance Business Efficiency

The AI logistics pharma platforms are re-inventing the flow of pharmaceutical products across the global networks. The smart logistics pharma industry solutions are designed with AI that helps in optimizing routes, carrier selection, warehouse operation, and real-time monitoring of cold chains. AI will play a role in pharmaceutical inventory management in 2026 based on autonomous inventory optimization. AI will keep recalibrating reorder points, safety stock and allocation strategies on multi-echelon networks.

Terminal operating systems: Modules, features, and top providers

AI models help businesses analyze existing routing and track route optimization.
Companies using AI-based demand forecasting lower inventory holding costs while improving order fulfillment rates.
This makes the last mile busier than ever and ripe for a technology disruption.
Artificial intelligence in turn is quickly becoming a strategic enabler in the worlds of logistics, inventory control and the overall coordination of a supply chain.
Each category addresses distinct operational challenges and highlights significant opportunities.

Early adopters of warehouse automation achieve fulfillment accuracy rates exceeding 99.5%. The Tariff Chaos post covers how trade volatility is actually accelerating AI adoption in logistics by making manual decision-making too slow and too costly. That creates a compliance-meets-operations use case that teams should understand. Logistics ranks among the top three industries for AI ROI potential, averaging 190% returns on AI investments. The 35% adoption rate means early movers capture disproportionate competitive advantage.

AI in logistics

How artificial intelligence is transforming logistics

A digital twin is an imaginary replica of the physical supply chain, which responds to real-time processes, assets, and flows. Digital twins can be used to enable pharmaceutical firms to simulate situations, analyze the risks, and test their decisions before deploying them in the real world, all using AI. The AI inventory management pharma solutions are changing the manner in which businesses maintain balance between stock and working capital efficiency.

This system is now being expanded to mid-tier suppliers and transportation rate negotiations. Research shows up to 90% of routine logistics manager tasks are automatable (e.g., via tools like predictive analytics), while mechanics and technicians face low automation risk. The shift reduces clerical roles but boosts demand for data analysts, AI supervisors, and decision-makers.

Data sharing is both a technical and governance challenge — see our logistics AI governance guide for approaches to multi-party AI accountability. AI success has become an operating model challenge, not simply a tool to be implemented where available. Organizations that master integration, change management, and outcome measurement will pull ahead, while those waiting for better technology or lower prices will fall further behind.

Dynamic route optimization

Prolifics helps enterprises operationalize real-time intelligence by modernizing data pipelines, enabling AI-ready architectures, and embedding intelligence directly into operational workflows.
The technology becomes increasingly accurate in future load-to-carrier matchings as it learns from millions of performed transactions each day.
The greatest returns begin in back-office workflows and visibility enhancements, with expanding potential in warehouses, sorting, and last-mile delivery.
Collectively, these six categories enable logistics firms to target cost reductions between 10% and 25% percent across operational pools such as selling, general, and administrative (SG&A), last-mile delivery, sorting, and warehouse management.
This paper examines how AI-driven sustainment can transform logistics operations in the Indo-Pacific, aligning with the Army’s multi-domain operations (MDO) doctrine and ensuring combat effectiveness in a highly contested theater.

In 2026, labor shortages and surging e-commerce demand are accelerating adoption, with facilities reporting 25–30% reductions in labor costs and fulfillment rates up to three times faster than traditional methods. Autonomous systems and AI integration allow warehouses to maintain near-perfect accuracy while scaling operations efficiently across thousands of facilities. Companies are restructuring supplier networks, adopting just-in-case (JIC) inventory models, and implementing AI-driven forecasting to anticipate and mitigate disruptions. The objective is to maintain operational continuity while balancing cost efficiency with risk https://ulstergrandprix.net/meet-the-sponsors-ifs-logistics/ management.

It addresses the challenges posed when communications are denied, disrupted, intermittent, or limited, allowing units to continue operations without relying on central servers. Artificial intelligence is involved at the mission planning stage to create a route that bypasses Russian air defense zones. The Ministry of Defence explained that the neural network onboard the drones also helps distinguish decoys from combat equipment. The algorithm compares object geometry, surface characteristics and engine heat signatures to improve target identification and ensure effective use of the system.

AI in logistics

Because these areas yield fast results, businesses concentrate on risk management, freight optimization, and workflow automation. Despite shippers’ growing expectations that their LSP partners offer AI capabilities, AI adoption among LSPs still lags significantly. (See Exhibit 2.) About 40% report deploying AI beyond pilots, yet only one in ten have embedded AI into core operations at scale. Only 13% report measurable value—such as improvements in unit costs, service levels, or margins—from embedding AI into daily operations.

AI in logistics

AI in logistics involves analyzing vast amounts of data to optimize operations and reduce inefficiencies. The Corporate Sustainability Reporting Directive requires Scope 3 emissions reporting across logistics chains. AI-assisted emissions calculation must comply with European Sustainability Reporting Standards (ESRS) methodology and survive external audit. Logistics firms handling goods for CSRD-reporting customers face indirect compliance pressure even if they are below direct CSRD thresholds. The World Economic Forum’s 2025 Supply Chain Governance Report found that 78% of logistics companies lack contractual clarity on AI accountability in multi-party operations.

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Pathologic Fractures Secondary to Primary Non-Hodgkin’s Lymphoma of Bone: A Report of Two Cases Treated with Surgery

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AI in Logistics and Supply Chain Management Market Report 2026

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AI in Logistics and Supply Chain Management Market Report 2026

best dealer management systems: Features, integrations, and top fit for your business

Top 11 AIaaS to Enhance Business Efficiency

Terminal operating systems: Modules, features, and top providers

How artificial intelligence is transforming logistics

Dynamic route optimization

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Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

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best dealer management systems: Features, integrations, and top fit for your business

Top 11 AIaaS to Enhance Business Efficiency

Terminal operating systems: Modules, features, and top providers

How artificial intelligence is transforming logistics

Dynamic route optimization

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Journal of Bone and Soft Tissue Tumors (JBST) Editorial Office

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Journal of Bone and Soft Tissue Tumors (JBST) License