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Pathologic Fractures Secondary to Primary Non-Hodgkin’s Lymphoma of Bone: A Report of Two Cases Treated with Surgery

December 31, 2021

Case Report | Volume 7 | Issue 3 | JBST September – December 2021 | Page 16-19 | Abigail R Tud, Celestine Marie G Trinidad. DOI:0.13107/jbst.2021.v07i03.61 Author: Abigail R Tud [1], Celestine Marie G Trinidad [2] [1] Musculoskeletal Tumor Unit, Philippine Orthopedic Center, Quezon City, Manila, Philippines. [2] Department of Pathology, Philippine Orthopedic Center, Quezon […]

Analysis of X-ray Patterns in Infection and Tumor

May 10, 2021

Cases Series | Volume 7 | Issue 2 | JBST May – August 2021 | Page 5-8 | Dominic Puthoor. DOI:10.13107/jbst.2021.v07i02.47 Author: Dominic Puthoor[1] [1]Department of Orthopaedic Oncologist, Amala Institute of Medical Sciences, Thrissur, Kerala, India. Address of Correspondence Dr. Dominic Puthoori, Department of Orthopaedic Oncologist, Amala Institute of Medical Sciences, Thrissur, Kerala, India. E-mail: […]

Pathologic Fractures Secondary to Primary Non-Hodgkin’s Lymphoma of Bone: A Report of Two Cases Treated with Surgery

December 31, 2021

Analysis of X-ray Patterns in Infection and Tumor

May 10, 2021

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Pathologic Fractures Secondary to Primary Non-Hodgkin’s Lymphoma of Bone: A Report of Two Cases Treated with Surgery

December 31, 2021

Author: Abigail R Tud [1], Celestine Marie G Trinidad [2]

[1] Musculoskeletal Tumor Unit, Philippine Orthopedic Center, Quezon City, Manila, Philippines.

[2] Department of Pathology, Philippine Orthopedic Center, Quezon City, Manila, Philippines.

Address of Correspondence
Dr. Abigail R Tud,
Musculoskeletal Tumor Unit, Philippine Orthopedic Center, Quezon City, Manila, Philippines.
E-mail: abitud.pocmtu@gmail.com

Abstract

Background: Primary lymphoma of bone (PLB) is a rare condition accounting for <2% of lymphomas among adults. Diagnosis is confirmed through clinical features, radiologic findings, and immunohistochemical studies. Treatment consists primarily of chemotherapy and radiotherapy. A lack of consensus remains, however, regarding the role of surgery on prognosis. Interventions with potential to improve quality of life therefore warrant further investigation. The authors report two cases of PLB treated with surgery, with favorable outcomes.
Case Presentation 1: A 21-year-old female presented with the left knee pain unaccompanied by constitutional symptoms. Imaging studies showed an isolated pathologic fracture of the left proximal tibia. Histopathology showed an atypical proliferation of large round cells, which stained diffusely and strongly positive for CD20. 90% of the cells also stained positive for the proliferation marker Ki-67. These findings were consistent with a high-grade B-Cell non-Hodgkin’s lymphoma (NHL). The tibial lesion was managed with direct fracture reduction and knee arthrodesis. Six cycles of chemotherapy were completed. Current Musculoskeletal Tumor Society (MSTS) score is 28/30, without evidence of recurrence 3 years post-surgery.
Case Presentation 2: A 69-year-old male sustained a pathologic subtrochanteric fracture after falling on his left hip. Diagnostic imaging revealed no other osseous lesions. Biopsy specimens showed a proliferation of atypical lymphoid cells, and on immunohistochemistry, these were diffusely and strongly positive for lymphocyte common antigen (CD45) and CD20. This was consistent with a high-grade B-Cell NHL. After proximal femoral nailing was performed, no further treatment was given. The patient is currently 2 years post-surgery with MSTS score of 28/30, and no signs of recurrence or metastases.

Conclusion: Current approach to treatment of PLB is multi-modal, but guidelines for surgical intervention are unavailable. Few reports have been made on outcomes after surgery. Pathologic fracture fixation is an option among select patients, affording satisfactory functional outcomes while minimizing morbidity.

Keywords: Knee resection arthrodesis, Non-Hodgkin’s lymphoma of bone, pathologic fracture, primary lymphoma of bone.

References:

1. Scoccianti G, Rigacci L, Puccini B, Campanacci DA, Simontacchi G, Bosi A, et al. Primary lymphoma of bone: outcome and role of surgery. Int Orthop 2013;37:2437-42.
2. Tsoucalas G, Papaioannou TG, Mainta I, Thomaidis V, Fiska A. A rare case of a non-Hodgkin’s lymphoma presented as a single bone lesion. Biomed J Sci Tech Res 2018;3:1-3.
3. Singh T, Satheesh CT, Lakshmaiah KC, Suresh TM, Babu GK, Lokanatha D, et al. Primary bone lymphoma: A report of two cases and review of the literature. J Can Res Ther 2010;6:296-8.
4. Coley BL, Higginbotham NL, Groesbeck HP. Primary reticulum cell sarcoma of bone; summary of 37 cases. Radiology 1950;55:641-58.
5. Jacobs AJ, Michels R, Stein J, Levin AS. Socioeconomic and demographic factors contributing to outcomes in patients with primary lymphoma of bone. J Bone Oncol 2015;4:32-6.
6. Jawad MU. Primary lymphoma of bone in adult patients. Cancer 2010;116:871-9.
7. Kitsoulis P, Vlychou M, Papoudou-Bai A, Karatzias G, Charchanti A, Agnantis NJ, et al. Primary lymphomas of bone. Anticancer Res 2006;26:325-38.
8. Mavrogenis AF, Angelini A, Pala E, Zinzani P, Ruggieri P. The role of surgery for haematologic neoplasms of bone. Acta Orthop Belg 2012;78:382-92.
9. Messina C, Christie D, Zucca E, Gospodarowicz M, Ferreri AJ. Primary and secondary bone lymphomas. Cancer Treatment Rev 2015;41:235-46.
10. Bhagavathi S, Fu K. Primary lymphoma of bone: Areview. Semin Diagn Pathol 2014;31:48-52.
11. Bhagavathi S, Micale MA, Les K, Wilson JD, Wiggins ML, Fu K. Primary bone diffuse large B-cell lymphoma. Am J Surg Pathol 2009;33:1463-9.

How to Cite this article: Tud AR, Trinidad CMG | Pathologic fractures secondary to primary non-Hodgkin’s lymphoma of bone: A report of two cases treated with surgery. | Journal of Bone and Soft Tissue Tumors | Sep-Dec 2021; 7(3): 16-19.

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Analysis of X-ray Patterns in Infection and Tumor

May 10, 2021

Author: Dominic Puthoor[1]

[1]Department of Orthopaedic Oncologist, Amala Institute of Medical Sciences, Thrissur, Kerala, India.

Address of Correspondence
Dr. Dominic Puthoori,
Department of Orthopaedic Oncologist, Amala Institute of Medical Sciences, Thrissur, Kerala, India.
E-mail: dkputhur@gmail.com

Abstract

Introduction: In diagnosis of bone tumor, X-ray is as important, if not more important than pathology report. However, X-ray had specific disadvantage. Tumor mimics especially infection can have same appearance as tumor in the X-ray. In this article, author analyzes the different patterns of X-ray changes common to tumor and infection and points outs that X-ray depicts the aggressiveness of the condition rather than a specific diagnosis.

Keywords: X-ray, Bone tumor, Tumor mimics.

References:
1. Mandal AK, Chaudhary S. Text Book of Pathology. Synapse Books. 1st ed. New Delhi, India: Avichal Publishing Company; 2010. p. 51, 113.
2. Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran Pathological Basis of Diseases. Amsterdam, Netherlands: Elsevier; 2010. p. 1205-35.
3. Enneking WF, Bertoni F, The staging system for benign and malignant tumours of the musculoskeletal system. In: Nadarajan M, editors. Article Written in Principles of Orthopedic Oncology; 1997. p. 112-20.
4. Shimose S, Sugita T, Kubo T, Matsuo T, Nobuto H, Ochi M. Differential diagnosis between osteomyelitis and bone tumors. Acta Radiol 2008;49:928-33.
5. Stacy GS, Kapur A. Mimics of bone and soft tissue neoplasms. Radiol Clin North Am 2011;49:1261-86.
6. Dorman HD, Czerniak B. Bone Tumors. 1st ed. United States: Mosby; 1998. p. 22.
7. Puthur D. X-ray patterns common to infection and tumours. Kerala J Orthop 2014;27:73-7.
8. Malawer MM, Sugarbaker PH. Musculoskeletal Cancer Surgery: Treatment of Sarcomas and Allied Diseases. Berlin, Germany: Springer; 2001. p. 59, 60.
9. Sutton D. Text Book of Radiology and Imaging. 7th ed. United Kingdom: Churchill Livingstone; 2003. p. 1153-60.
10. Miwa S, Otsuka T. Practical use of imaging technique for management of bone and soft tissue tumors. J Orthop Sci 2017;22:391-400.

How to Cite this article: Puthoor D | Analysis of X-ray patterns in infection and tumor. | Journal of Bone and Soft Tissue Tumors | May-August 2021; 7(2): 5-8.

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Pathologic Fractures Secondary to Primary Non-Hodgkin’s Lymphoma of Bone: A Report of Two Cases Treated with Surgery

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Analysis of X-ray Patterns in Infection and Tumor

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Pathologic Fractures Secondary to Primary Non-Hodgkin’s Lymphoma of Bone: A Report of Two Cases Treated with Surgery

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Analysis of X-ray Patterns in Infection and Tumor

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