Primary Leiomyosarcoma of the Hip Bone: A Case Report and Literature Review

Vol 5 | Issue 3 | September – December 2019 | page: 5-7 | Dr. Francisco de Assis Serra Baima Filho.

Author: Francisco de Assis Serra Baima Filho [1].

[1] Department of Orthopedic Oncology, Aldenora Bello Oncology Institute of Maranhao, Brazil.

Address of Correspondence
Dr. Francisco de Assis Serra Baima Filho,
Department of Orthopedic Oncology, Aldenora Bello Orthopedic Oncology Institute of Maranhao (IMOAB), Brazil.
E-mail: assisbaima@gmail.com

Abstract

Introduction: Leiomyosarcoma is a rare smooth muscle mesenchymal neoplasm. The primary bone form is the rarest subtype. It mainly affects middle aged and female people. The most common complaint is the presence of a mass accompanied by pain. Diagnostic imaging and biopsy are required. The gold standard treatment is resection with oncologic margin.
Case Report: A 20-year-old female had a history of tumor mass and left hip pain beginning in September 2018.The patient showed the radiographic examination, osteolytic lesion of the left hip, and computed tomography scan of the abdomen with a solid expansive process measuring 15.8 cm left hip destruction and absence of organ damage. Biopsy and immunohistochemical result of leiomyosarcoma. Neoadjuvant chemotherapy was not effective. Thus, we opted for tumor resection with internal hemipelvectomy Type I.
Conclusion: Primary bone leiomyosarcoma is a rare malignant neoplasm which only shows tumoral resection with oncological margins as a curative treatment, thus the need for early diagnosis to allow adequate resection and lower patient morbidity.
Keywords: Leiomyosarcoma, case reports, rare diseases, literature review.

References

1. Gordon RW, Tirumani SH, Kurra V, Shinagare AB, Jagannathan JP, Hornick JL, et al. MRI, MDCT features, and clinical outcome of extremity leiomyosarcomas: Experience in 47 patients. Skeletal Radiol2014;43:615- 22.
2. Tahara K, Yamashita K, Hiwatashi A, Togao O, Kikuchi K, Endo M, et al. MR imaging findings of a leiomyosarcoma of the thoracic spine: A case report. Clin Neuroradiol 2016;26:229-33.
3. Mori T, Nakayama R, Endo M, Hiraga H, Tomita M, Fukase N, et al. Fortyeight cases of leiomyosarcoma of bone in Japan: A multicenter study from
the Japanese musculoskeletal oncology group. J Surg Oncol 2016;114:495-500.
4. Rekhi B, Kaur A, Puri A, Desai S, Jambhekar NA. Primary leiomyosarcoma of bone–a clinicopathologic study of 8 uncommon cases
with immunohistochemical analysis and clinical outcomes. Ann Diagn Pathol2011;15:147-56.
5. Potsi M, Stavrinou P, Patsinakidis N, Hatzibougias D, Foroglou N, Karayanopoulou G, et al. Primary osseous leiomyosarcoma of the spine: A
rare entity–case report and review of the literature. J Neurol Surg A Cent Eur Neurosurg2012;73:238-42.
6. Yang Y, Ma L, Li L, Liu H. Primary leiomyosarcoma of the spine: A case report and literature review. Medicine (Baltimore) 2017;96:e6227.
7. Zumárraga JP, Arouca MM, Baptista AM, Caiero MT, Rubio DE, Camargo OP. Primary leiomyosarcoma of bone: Clinicopathologic and
prognostic factors analysis in a single institution. Acta Ortopédica Bras 2019;27:152-5.
8. Recine F, Bongiovanni A, Casadei R, Pieri F, Riva N, De Vita A, et al. Primary leiomyosarcoma of the bone: A case report and a review of the literature. Medicine (Baltimore) 2017;96:e8545.

How to Cite this article:  De Assis Serra Baima Filho F | Primary Leiomyosarcoma of the Hip Bone: A Case Report and Literature Review | Journal of Bone and Soft Tissue Tumors | Sep-Dec 2019;5(3): 5-7.

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Osteoid Osteoma Radiofrequency Ablation Treatment using a Kirschner Wireguided with a Scope: A Case Report and Literature Review

Vol 5 | Issue 3 | September – December 2019 | page: 2-4 | Dr. Francisco de Assis Serra Baima Filho.

Author: Francisco de Assis Serra Baima Filho [1].

[1] Department of Orthopedic Oncology, Aldenora Bello Oncology Institute of Maranhao, Brazil.

Address of Correspondence
Dr. Francisco de Assis Serra Baima Filho,
Department of Orthopedic Oncology, Aldenora Bello Orthopedic Oncology Institute of Maranhao (IMOAB), Brazil.
E-mail: assisbaima@gmail.com

Abstract

Introduction: Osteoid osteoma is a benign tumor and is the third most common bone tumor. It is <2cm and characterized by very intense clinical pain at night which lets up after taking two nonsteroid anti-inflammatory drugs. Conventionally, the surgical treatment performed was resection or curettage. At present, the recommended treatment is computed tomography (CT)-guided radio frequency due to the high efficacy rate and low comorbidity.
Case Report: A 29-year-old male patient diagnosed with an osteoid osteoma in a small right femoral trochanter. Due to the location of the tumor, we opted for a percutaneous treatment, but it was not possible to be submitted to CT-guided radio frequency due to the high costs. Thus, the scope-guided Kirschner wire radioablation technique was developed.
Discussion: At present, CT-guided radio frequency ablation is the most commonly used method due to its safety, high efficacy (over 90%), and minimally invasive. However, there are disadvantages: Problems with sterility of the radiological set, radiation, and high risk of thermal the skin and soft tissue necrosis. New treatment methods are under development, but they are even more costly.
Conclusion: Due to its high costs, many patients, especially from underdeveloped countries, donot undergo this treatment and are reserved to open surgical treatment with resection or curettage. Therefore, the development of low-cost minimally invasive percutaneous techniques is necessary.
Keywords: Osteoid osteoma (MeSH ID: D010017), case report (MeSH ID: D002363), rare diseases (MeSH ID: D035583), literature review (MeSH ID: D016454).

References

1. Göksel F, Aycan A, Ermutlu C, Gölge UH, Sarisözen B. Comparison of radiofrequency ablation and curettage in osteoid osteoma in children. Acta Ortop Bras 2019;27:100-3.
2. Gurkan V, Erdogan O. Foot and ankle osteoid osteomas. J Foot Ankle Surg 2018;57:826-32.
3. Rinzler ES, Shivaram GM, Shaw DW, Monroe EJ, Koo KS. Microwave ablation of osteoid osteoma: Initial experience and efficacy. Pediatr Radiol 2019;49:566-70.
4. Hage AN, Chick JF, Gemmete JJ, Grove JJ, Srinivasa RN. Percutaneous radiofrequency ablation for the treatment of osteoid osteoma in children and adults: A comparative analysis in 92 patients. Cardiovasc Intervent Radiol 2018;41:1384-90.
5. Santiago E, Pauly V, Brun G, Guenoun D, Champsaur P, Le Corroller T. Percutaneous cryoablation for the treatment of osteoid osteoma in the adult population. Eur Radiol 2018;28:2336-44.
6. Shields DW, Sohrabi S, Crane EO, Nicholas C, Mahendra A. Radiofrequency ablation for osteoid osteoma-recurrence rates and predictive factors. Surgeon 2018;16:156-62.
7. Cuesta HE, Villagran JM, Horcajadas AB, Kassarjian A, Caravaca GR. Percutaneous radiofrequency ablation in osteoid ostema: Tips and tricks in special scenarios. Eur J Radiol 2018;102:169-75.
8. Miyazaki M, Saito K, Yanagawa T, Chikuda H, Tsushima Y. Phase I clinical trial of percutaneous cryoablation for osteoid osteoma. Jpn J Radiol 2018;36:669-75.
9. Erdogan O, Gurkan V. Hand osteoid osteoma: Evaluation of diagnosis and treatment. Eur J Med Res 2019;24:1-5.
10. Doyle AJ, Graydon AJ, Hanlon MM, French JG. Radiofrequency ablation of osteoid osteoma: Aiming for excellent outcomes in an Australasian context. J Med Imaging Radiat Oncol 2018;62:789-93.

How to Cite this article:  de Assis Serra Baima Filho F | Osteoid Osteoma Radiofrequency Ablation Treatment using a Kirschner Wire-guided with a Scope: A Case Report and Literature Review | Journal of Bone and Soft Tissue Tumors | Sep-Dec 2019; 5(3): 2-4.

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Take www.talktowendys.com Wendy Survey

Talktowendys provides you an opportunity to share your experience, views, and opinions. This survey is mainly conducted to know the customer’s satisfaction levels. After receiving the feedback information, the company will try to meet the customer’s expectations in order to make them happy. The survey is conducted on www.talktowendys.com. At the end of the survey, customers will be rewarded for participating in the survey. We have provided the Talktowendys Survey instructions for your ease.

Wendys survey is designed to gather customer feedback. The purpose of wendys survey is to improve customer experience in regards to food quality and services provided by talktowendys.com. TalkToWendys encourage honest feedback so that they can focus on provided issues and concerns. Based on customer experience, employee improvement is noted and then Wendys make sure to focus on improving staff training.

Customers can take the wendys survey on talktowendys.com at any time. However, there are certain rules and regulations that you need to adhere in order to take and complete the Wendys survey successfully. Wendys survey doesn’t take long to complete, all you need to do is to answer a few questions based on your previous experience at TalkToWendys.

TalktoWendys Customer Survey

  1. Go to the official survey website at www.wendyswantstoknow.com
  2. Choose your language
  3. Now, enter the 8-digit restaurant number located at the top of your receipt
  4. Type the date as printed on the store receipt
  5. Enter your active email address
  6. Click next
  7. Read the questions carefully asked by the site.
  8. Answer each of them and if you wish, add any extra information in the space provided.
  9. After answering all questions, you will receive a coupon via your email address.
  10. Sign in to your email account and find the email from Wendy
  11. Print the coupon you received
  12. Congrats for getting a free coupon.

RULES

You must be 18 years of age, or older to participate in the survey.
You must have a purchase receipt from your recent visit to Wendy’s.
You have to take the survey in one language from English, French or Spanish.
You can only get one upon finishing the survey.
You must use the coupon before it expires.

INSTRUCTIONS

Visit any nearby Wendy’s and make a purchase.
Keep the purchase receipt with you.
Make sure you have a PC or a Smartphone with internet access.
Visit www.talktowendys.com from your PC or Smartphone.
Use the code that is printed on your receipt to enter into the survey.
Start the survey and answer all the questions to finish it.
You’ll receive a free coupon code after finishing the survey, save it.
Use the coupon code within the next 14 days to get your free BOGO Sandwich.

What are the questions about?

Just like any other survey, Wendy’s restoring survey questions are for faithful customers to answer. It comprises of questions about the restaurant and their services. They address some of the following issues:

  • Restaurant services- They want to know how you were treated while on their premises? Where the workers friendly and did you get what you ordered? Did they get the order right? Also, is the premise clean as you want?
  • Food quality and quantity- Did the quality of the food satisfy you, was it enough? Any issue about the cooking and serving of the food. They want to know your views on that. Did the food taste as you expected? Let them know so that they can change in the future.
  • Payment services- How did you pay for your dish, did you have difficulties hen paying and which mode of payment would you like them to add? If you were purchasing for a takeaway, how was the process and was it as you wanted.

How To Participate In Whataburger Survey

Presenting an opportunity for the customers to have their opinions heard, Whataburger would like you to participate in the Whataburger Survey over at the official website www.whataburgersurvey.com. The WhataburgerExperience survey gives you, the customer, the chance to share your experience and offer advice or suggestions on how the food and services could be improved. In return for the efforts you put into the survey, you get rewarded with a free Whataburger to tickle your taste buds.

Whataburger has focused on its fresh, made-to-order burgers and friendly customer service since 1950 when Harmon Dobson opened the first Whataburger as a small roadside burger stands in Corpus Christi, Texas. Dobson gave his restaurant a name he hoped to hear customers say every time they took a bite of his made-to-order burgers: “What a burger!”

The reason behind restaurants conducting surveys is to know customers opinion on the food. To know whether the customer is satisfied or not. Customer satisfaction plays a crucial role in a restaurant’s success and progress. So Whataburger is also looking to ensure customer satisfaction. To know whether a customer is satisfied or not, you should ask. Hence, this survey from ChuckAlek Feedbacks.

Objectives of Whataburger Survey

There is a cost related to every action a company takes, so everything they do has a reason. So, a company has objectives for everything you do. So, let’s have a look at the objectives of Whataburger behind this survey:

  • To get to know the customer’s point of view, how they judge the services of the restaurant they went to.
  • To ensure that they are satisfying their needs and expectations. But to fulfill their expectations, they need to know what the expectations are in the first place. And to know the expectations, a survey is the best method.
  • To help the restaurant improve various aspects of it by knowing what the customer thinks about it.
  • This survey also helps the management to figure out how a store is performing.
  • If something goes wrong, customers can help throw light at it and the problem can be dealt with at the management level itself.

How To Participate In The Whataburger Survey

Before participating in the survey, one must know the rules and regulations one needs to follow and fulfill. Read each and every point carefully. Here you go

Rules and Regulations

  1. The person participating in the survey should be a legal resident of The United States of America.
  2. The bill receipt should be of a recent visit and should be valid.
  3. The specific person participating in the review should be of an age 16 years and above.
  4. One must participate in the survey within a limited period of time from the visit. The receipt might be noted as invalid if you are too late.
  5. With one receipt one customer can participate only once. If you have more than one receipt then the same person can participate once more.
  6. The employees of Whataburger or their family members or agents are not eligible to participate in the survey.
  7. After the completion of the survey, you will receive a gift card. Make sure you redeem your gift card before it expires.

How To Take The Whataburger Survey

  • Purchase something at a Whataburger and save your receipt
  • Visit the Whataburger Survey page and take the online survey
  • If your receipt doesn’t have a survey code, take the survey here instead
  • Save your code to redeem your free gift on your next Whataburger visit

Best The Forest Mods You Can’t Play Without

The Forest is a popular survival game that’s been in Early Access for years now and finally got it’s full release earlier this year. It’s a first-person survival game in the vein of Rust or DayZ, where players must survive after waking from a crashed plane in an ominous and mysterious forest. The game features an extensive multiplayer mode, where you can survive with others, or choose to hunt down others if you so wish.

The Forest mods can be a bit difficult since these games modding hasn’t been around for as long as those of other titles. The open-world survival game officially launched a little over a year ago so people have yet to come up with a ton of modifications for it just yet. Despite its relatively young age, however, there are already a handful of mods out there that are definitely worth picking up if you want to spice up your game a little bit.

With that in mind, we rounded up some of The Forest Mods from BOC you can grab right now and place them all into a neat little list for you to enjoy. We also added download links for each of them to make things even easier for you. If you’ve never played the game before it’s probably a good idea to try out the vanilla version first before installing any mods. But if you’re already a seasoned veteran, the mods below will give you something new to look forward to the next time you boot up the game.

Best The Forest Mods

Like my grandfather used to always say, there’s nothing worse than getting lost in the deep dark woods, especially when it’s teeming with cannibals. Arming yourself with this handy dandy map will have all of those suckers marked right there, so you’ll never be caught flatfooted again.

You will also be able to see the location of all players on your server. You can hover over their icon to view their name, should you be so inclined.

It’s important to know the identity of your allies in the quest for survival, even if it’s something as unfortunate as FartsOfFury.

If you’re noticing some visual inconsistencies here, please note that the included picture isn’t from the mod, but rather from the interactive map painstakingly created by a community member.

This is also very helpful, but not mod-related, so we shan’t extrapolate further. Let’s just tip our hats to the cartographers who make our lives easier.

In-Game Crosshairs

Like me, you may have a little trouble with aiming your gun or bow. I always rely on crosshairs for shooting quickly so this Mod is fantastic for anyone who needs a little help when aiming!

As the name suggests, this Mod enables crosshairs, so you have a better aim when you need to take down Mutants or cannibals. We all know cannibals and Mutants hate fire, so this will help when you next need to get your first throw correct!

SERVERMOD

There aren’t a lot of mods that affect the server in The Forest and Mods for Sims 3. However, this one does. ServerMod adds a few new settings, such as regrowing 2-5% of trees every night. Post in chat when a player is dying, as well as posting when a player connects and disconnects. These are more just quality of life changes.

TREE RESPAWN

By default, around 10% of trees regrow every night in The Forest. Sometimes, this might not be enough, depending on how many you’re cutting down each night. When you install the Tree Re-spawn mod, you can instantly re-spawn 10% of all missing trees by holding SHIFT & pressing R.

EASY BUILDING

The Easy Building mod for The Forest is a balancing mod. It aims to reduce the building cost of every structure and building in the game by half. This is definitely a welcomed mod if you’re struggling to build a base with defenses.

Identification of Breast Cancer Patients at Risk for Bone Metastasis – A Case–Control Study

Case Report | Volume 5 | Issue 2 | JBST May – August 2019 | Page 15-19| Purnima Thakur, Vishal Verma, Ekta Dogra, Ankur Gupta, Manish Gupta, Vikas Fotedar. DOI: 10.13107/jbst.2019.v05i02.430

Author Purnima Thakur[1], Vishal Verma[2], Ekta Dogra[3], Ankur Gupta[4], Manish Gupta[1], Vikas Fotedar[1]
[1]Department of Radiotherapy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India,
[2]Department of Orthopedics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India,
[3]Department of Community Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India,
[4]Department of Anatomy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Address of Correspondence
Dr. Vishal Verma,
Department of Orthopedics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
E-mail: vishhal82@gmail.com

Abstract
Introduction: Prognostic factors for metastatic breast carcinoma are a less studied topic than a prognostic factor for primary breast cancer. Bone is the most frequent site for metastasis in breast cancer patients. Bone metastasis decreases the survival and impacts the quality of life(QoL)in breast cancer patients. Therefore, the study to identify prognostic factors of this specific group of patients appears to be worthy of more detailed study. To the best of our knowledge, this is the first study of its kind in the North Indian population.
Materials and Methods: A retrospective case–control study was conducted at a tertiary cancer centerin Northern India between January 2011 and December 2015. All patients’ clinical and demographic data were obtained from the medical record of the institute. The incidence and distribution of bone metastases from breast cancer were evaluated, and the correlation between diverse clinical-pathological parameters and bone metastases were analyzed in this study.
Results: A total of 363 patients were recruited, including 94 cases with bone metastases and 269 controls without bone metastases at presentation. Positive axillary lymph node status, higher stage tumors, HER2 neu-negative disease, and histological subtypes of tumor were found significant prognostic factors in univariate analysis associated with higher rates of bone metastasis. Luminal A(estrogen receptor-positive [ER+], progesterone receptor-positive [PR+], HER2–ve, Grade 1,2), and HER 2 enriched (ER –ve, PR–ve, and HER 2+) molecular subtypes are associated with increased risk of bone metastasis. None of the risk factors studied were significantly associated with bonemetastasis in binary logistic regression analysis.
Conclusion: Identification of breast cancer patients at risk for bone metastasis may aid in the prevention, prediction, detection, and early treatment of these lesions, thus providing improved survival and better QoL.
Keywords: Bone metastasis, risk factors, breast cancer.

References
1. Liede A, Jerzak KJ, Hernandez RK, Wade SW, Sun P, Narod SA, et al. The incidence of bone metastasis after early-stage breast cancer in Canada. Breast Cancer Res Treat 2016;156:587-95.
2. Coleman RE. Metastatic bone disease: Clinical features, pathophysiology and treatment strategies. Cancer Treat Rev 2001;27:165-76.
3. Koizumi M, Yoshimoto M, Kasumi F, Iwase T, Ogata E. Post-operative breast cancer patients diagnosed with skeletal metastasis without bone pain had fewer skeletal-related events and deaths than those with bone pain. BMC Cancer 2010;10:423.
4. Cramarossa G, Chow E, Zhang L, Bedard G, Zeng L, Sahgal A, et al. Predictive factors for overall quality of life in patients with advanced cancer. Support Care Cancer 2013;21:1709-16.
5. Lee SJ, Park S, Ahn HK, Yi JH, Cho EY, Sun JM, et al. Implications of bone-only metastases in breast cancer: Favorable preference with excellent outcomes of hormone receptor positive breast cancer. Cancer Res Treat 2011;43:89-95.
6. Ahn SG, Lee HM, Cho SH, Lee SA, Hwang SH, Jeong J, et al. Prognostic factors for patients with bone-only metastasis in breast cancer. Yonsei Med J 2013;54:1168-77.
7. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D, et al. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
8. Parkin DM. Cancer base No. 7. In: Cancer Incidence in Five Continents. Vol. 1-8. Lyon: IARC Press; 2005.
9. Brockton NT, Gill SJ, Laborge SL, Paterson AH, Cook LS, Vogel HJ, et al. The breast cancer to bone (B2B) metastases research program: A multi-disciplinary investigation of bone metastases from breast cancer. BMC Cancer 2015;15:512.
10. Pulido C, Vendrell I, Ferreira AR, Casimiro S, Mansinho A, Alho I, et al. Bone metastasis risk factors in breast cancer. Ecancermedicalscience2017;11:715.
11. Chen WZ, Shen JF, Zhou Y, Chen XY, Liu JM, Liu ZL, et al. Clinical characteristics and risk factors for developing bone metastases in patients with breast cancer. Sci Rep 2017;7:11325.
12. Colleoni M, O’Neill A, Goldhirsch A, Gelber RD, Bonetti M, Thürlimann B, et al. Identifying breast cancer patients at high risk for bone metastases. J Clin Oncol 2000;18:3925-35.
13. James JJ, Evans AJ, Pinder SE, Gutteridge E, Cheung KL, Chan S, et al. Bone metastases from breast carcinoma: Histopathological radiological correlations and prognostic features. Br J Cancer 2003;89:660-5.
14. Purushotham A, Shamil E, Cariati M, Agbaje O, Muhidin A, Gillett C, et al. Age at diagnosis and distant metastasis in breast cancera surprising inverse relationship. Eur J Cancer 2014;50:1697-705.
15. Xiao W, Zheng S, Yang A, Zhang X, Zou Y, Tang H, et al. Breast cancer subtypes and the risk of distant metastasis at initial diagnosis: A population-based study. Cancer Manag Res 2018;10:5329-38.
16. Diessner J, Wischnewsky M, Stüber T, Stein R, Krockenberger M, Häusler S, et al. Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer. BMC Cancer 2016;16:307.
17. Irawan C, Hukom R, Prayogo N. Factors associated with bone metastasis in breast cancer: A preliminary study in an Indonesian population. Acta Med Indones2008;40:178-80.
18. Coleman RE, Rubens RD. The clinical course of bone metastases from breast cancer. Br J Cancer 1987;55:61-6.
19. Huszno J, Nowara E. Risk factors for disease progression in HER2-positive breast cancer patients based on the location of metastases. PrzMenopauzalny2015;14:173-7.
20. Yazdani A, Dorri S, Atashi A, Shirafkan H, Zabolinezhad H. Bone metastasis prognostic factors in breast cancer. Breast Cancer (Auckl) 2019;13:1178223419830978.

Dr. Purnima Thakur Dr. Vishal Verma Dr. Ekta Dogra Dr. Ankur Gupta Dr. Manish Gupta Dr. Vikas Fotedar

 

How to Cite this article: Thakur P, Verma V, Dogra E, Gupta A, Gupta M, Fotedar V. Identification of Breast Cancer Patients at Risk for Bone Metastasis – A Case–Control Study. Journal of Bone and Soft Tissue Tumors May-August 2019;5(2): 15-19.

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