Giant Ancient Solitary Schwannoma Masquerading as Juxtacortical Osteosarcoma of Femur – A Rare Case Report and Literature Review

Vol 5 | Issue 1 | Jan-April 2019 | page: 28-30 | Julfiqar, Mohd. Aslam, Najmul Huda, Ajay Pant.


Authors: Julfiqar [1], Mohd. Aslam [1], Najmul Huda [1], Ajay Pant [1].

[1] Dept of Orthopaedic Surgery, Faculty of Medicine, J.N.Medical College, Aligarh Muslim University, Aligarh, India
[2] Department of Orthopaedics, Teerthanker Mahaveer Medical College and Research Centre, TMU, Moradabad, India

Address of Correspondence
Dr. Julfiqar:
Assistant professor, Department of Orthopaedic Surgery, Faculty of Medicine, J.N.Medical College, Aligarh Muslim University, Aligarh, India.
Email: ???


Abstract

Introduction: Ancient schwannomas are rare variant of peripheral nerve sheath tumors characterized by the degeneration and hypocellular areas due to long-standing growth. Clinicoradiologically, these tumors can masquerade other tumors arising from the adjacent tissues. Their resemblance to malignant bone tumor has been reported very rarely in the literature. We tend to report a case of benign peripheral nerve schwannoma that greatly mimicked a juxtacortical osteosarcoma of femur.
Case Report: A 23-year-old male presented with a slow-growing painless mass with paresthesias in his right thigh for the last 2½ years. Clinically, it was suspected to be soft tissue tumor with secondary involvement of adjacent neurovascular bundle; however, plain radiograph and magnetic resonance imaging of his right thigh were suggestive of juxtacortical osteosarcoma of the right femur. Surgical exploration of the mass revealed a well-defined encapsulated mass over the anterior aspect of the right thigh, under the quadriceps muscle without infiltration into the surrounding tissue. Histopathological examination confirmed it to be an ancient schwannoma.
Results: The patient was extremely satisfied with outcomes of surgery, and he was symptom-free and there was no clinical evidence of the recurrence on subsequent follow-up.
Conclusion: A correct pre-operative diagnosis of benign peripheral nerve sheath tumors can be difficult at times. However, a slow-growing mass with the absence of other features of a malignant growth and subsequent histopathological examination including immunostaining can settle the diagnosis in almost all the cases.
Keywords: Benign, Peripheral nerve, Ancient schwannoma, Juxtacortical osteosarcoma.


References

1. Dahl I. Ancient neurilemmoma (schwannoma). Acta Pathol Microbiol Scand 1977;85:812-8.
2. Kuriakose S, Vikram S, Salih S, Balasubramanian S, Pareekutty NM, Nayanar S. Unique surgical issues in the management of a giant retroperitoneal schwannoma and brief review of literature. Case Rep Med 2014;2014:781347.
3. Isobe K, Shimizu T, Akahane T, Kato H. Imaging of ancient schwannoma. AJR Am J Roentgenol 2004;183:331-6.
4. Mwaka ES, Senyonjo P, Kakyama M, Nyati M, Orwotho N, Lukande R. Giant, solitary, ancient schwannoma of the cervico-thoracic spine: A case report and review of the literature. OA Case Reports 2013;2:2.
5. Choudry HA, Nikfarjam M, Liang JJ, Kimchi ET, Conter R, Gusani NJ, et al. Diagnosis and management of retroperitoneal ancient schwannomas. World J Surg Oncol 2009;7:12.
6. Jayaraj SM, Levine T, Frosh AC, Almyeda JS. Ancient schwannoma masquerading as parotid pleomorphic adenoma. J Laryngol Otol 1997;111:1088-90.
7. Lee YS, Kim JO, Park SE. Ancient schwannoma of the thigh mimicking a malignant tumour: A report of two cases, with emphasis on MRI findings. Br J Radiol 2010;83:e154-7.
8. Ackerman LV, Taylor FH. Neurogenous tumors within the thorax; A clinicopathological evaluation of forty-eight cases. Cancer 1951;4:669-91.
9. Enzinger FM, Weiss SW. Benign tumours of peripheral nerves. Soft Tissue Tumours. 3rd ed. St Louis: Mosby; 1995. p. 821-88.
10. Takeuchi M, Matsuzaki K, Nishitani H, Uehara H. Ancient schwannoma of the female pelvis. Abdom Imaging 2008;33:247-52.
11. Kransdorf MJ, Murphey MD, editors. Neurogenic tumours. Imaging of Neurogenic Tumours. 2nd ed. Philadelphia, PA: Lippincot Williams &Wilkins; 2006. p. 328-80.
12. Dahlin DC, Coventy MB. Osteogenic sarcoma: A study of six hundred cases. J Bone Joint Surg Am 1967;49:101-10.
13. Wong KT, Haywood T, Dalinka MK, Kneeland B. Chondroblastic, grade 3 periosteal osteosarcoma. Skeletal Radiol 1995;24:69-71.
14. Sorensen DM, Gokden M, El-Naggar A, Byers RM. Quiz case 1. Periosteal osteosarcoma (PO) of the mandible. Arch Otolaryngol Head Neck Surg 2000;126:550, 552.
15. Murphey MD, Jelinek JS, Temple HD, Flemming DJ, Gannon FH. Imaging of periosteal osteosarcoma: Radiologic-pathologic comparison. Radiol 2004;233:129-38.


How to Cite this article: Julfiqar, Aslam M, Huda N, Pant A. Giant Ancient Solitary Schwannoma Masquerading as Juxtacortical Osteosarcoma of Femur-A Rare Case Report and Literature Review. Journal of Bone and Soft Tissue Tumors Jan-April 2019;5(1): 28-30.


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Chondroblastoma of the Naviculum: A Diagnostic Dilemma

Vol 5 | Issue 1 | Jan-April 2019 | page: 25-27 | Monish Malhotra, Sandeep Vijayan, Sourab Shetty.


Authors: Monish Malhotra [1], Sandeep Vijayan [2], Sourab Shetty [2].

[1] Department of Orthopaedics, Pandit Bhagwat Dayal Sharma PGIMS, Rohtak, Haryana, India,
[2] Department of Orthopaedics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Address of Correspondence
Dr. Monish Malhotra,
Department of Orthopaedics, Pandit Bhagwat Dayal Sharma PGIMS, Rohtak – 124001, Haryana, India.
E-mail: drmonish.malhotra14@gmail.com


Abstract

Introduction: Chondroblastoma is a benign tumor characteristically seen in the epiphyseal region of long bones. Its occurrence in the tarsal bones is extremely rare.
Case Report: We report the case of a 17-year-old girl with chondroblastoma mimicking an aneurysmal bone cyst in the naviculum. Along with the primary enbloc excision of the naviculum, a tricortical iliac crest bone graft was placed in the gap to prevent collapse of the medial longitudinal arch.
Conclusion: Chondroblastoma in uncommon sites can present with atypical features and cause dilemma in diagnosis and thereby management.
Keywords: Chondroblastoma, Bone grafting, Aneurysmal bone cyst, Tarsal bones, Naviculum.


References

1. Suneja R, Grimer RJ, Belthur M, Jeys L, Carter SR, Tillman RM, et al. Chondroblastoma of bone: Long-term results and functional outcome after intralesional curettage. J Bone Joint Surg Br 2005;87:974-8.
2. Li XN, Peng ZG, Zhao JP, Zhang ZK. Chondroblastoma of the navicular bone. Iran J Radiol 2014;11:e10848.
3. Fang Z, Chen M. Chondroblastoma associated with aneurysmal cyst of the navicular bone: A case report. World J Surg Oncol 2013;11:50.
4. Springfield DS, Capanna R, Gherlinzoni F, Picci P, Campanacci M. Chondroblastoma. A review of seventy cases. J Bone Joint Surg Am 1985;67:748-55.
5. McLeod RA, Beabout JW. The roentgenographic features of chondroblastoma. Am J Roentgenol Radium Ther Nucl Med 1973;118:464-71.
6. Atalar H, Basarir K, Yildiz Y, Erekul S, Saglik Y. Management of chondroblastoma: Retrospective review of 28 patients. J Orthop Sci 2007;12:334-40.
7. Huvos AG, Marcove RC. Chondroblastoma of bone. A critical review. Clin Orthop Relat Res 1973;95:300-12.


How to Cite this article: Malhotra M, Vijayan S, Shetty S. Chondroblastoma of theNaviculum: A Diagnostic Dilemma. Journal of Bone and Soft Tissue Tumors Jan-Apr 2019;5(1): 25-27.


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Parosteal Lipoma of the Lower Limb: A Report of Two Cases

Vol 5 | Issue 1 | Jan-April 2019 | page: 21-24 | Imed Sboui, Hend Riahi, Mouna Chelli-Bouaziz, Mohamed Samir Daghfous, Mohamed Fethi Ladeb, Faten Farah.


Authors: Imed Sboui [1], Hend Riahi [2], Mouna Chelli-Bouaziz[2], Mohamed Samir Daghfous [1], Mohamed Fethi Ladeb [2], Faten Farah [3].

[1] Department of Orthopaedic, Institut Mohamed Kassab d’orthopédie, Manouba, Tunisia,
[2] Department of Radiology, Institut Mohamed Kassab d’orthopédie, Manouba, Tunisia,
[3] Department of Pathology, Institut Mohamed Kassab d’orthopédie, Manouba, Tunisia.

Address of Correspondence
Dr. Hend Riahi,
10 rue Khalifas Rachidites Menzeh 5 Ariana Tunisia.
E-mail: hend.riahi@gmail.com


Abstract

Introduction: Parosteal lipoma is a rare type of lipoma. Usually, asymptomatic and affecting mainly adults aged over 40.
Case Report: We report two cases localized in the lower limb. The first happened in a man presenting a painless swelling of the fibula, represented by a well-defined fatty tissue lesion. The second case concerned women presenting an asymmetry of the calf, represented by a well-defined mass composed of fatty tissue. The lesions were resected from surrounding soft tissues and underlying periosteum. The diagnosis was confirmed by histology.
Conclusion: Parosteal lipoma has the same characteristics of computed tomography (CT) and magnetic resonance imaging (MRI) as subcutaneous fat. The identification of fat is best performed with CT or MRI. Its recognition is mandatory to optimize clinical management including diagnosis, biopsy, and treatment.
Keywords: Deep-seated lipoma, Computed tomography, Magnetic resonance imaging.


References

1. Fleming RJ, Alpert M, Garcia A. Parosteal lipoma. AJR Am J Roentgenol 1962;87:1075-84.
2. Rodriguez-Peralto JL, Lopez-Barea F, Gonzales-Lopes J, Lamas-Lorenzo M. Case report 821. Skeletal Radiol 1994;23:67-9.
3. Asirvatham R, Linjawi T. Ossifying parosteal lipoma with exuberant cortical reaction. A case report. Int Orthop 1994;18:55-6.
4. Amores-Ramírez F, Hierro Martín I, Montañez Heredia E, Garcia-Fortea P, Garcia Salguero AI, Fernandez de Rota Conde A, et al. Painless mass in leg: Diagnosis and discussion. Skeletal Radiol 2009;38:1105-6, 1119-20.
5. Murphey MD, Johnson DL, Bhatia PS, Neff JR, Rosenthal HG, Walker CW, et al. Parosteal lipoma: MR imaging characteristics. AJR Am J Roentgenol 1994;162:105-10.
6. Schajowicz F. Neoplasia Óssea e Lesões Pseudotumorais. 2nd ed. Rio de Janeiro: Revinter; 2000. p. 403-46.
7. John SH, Chad CB, Kathleen SB, Valerie AF, Marcia FB, Joseph B. Parosteal lipoma of the proximal radius. Austin J Musculoskelet Disord 2016;3:1027.
8. Murphey MD, Arcara LK, Fanburg-Smith J. From the archives of the AFIP: Imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics 2005;25:1371-95.
9. Murphey MD, Carroll JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ, et al. From the archives of the AFIP: Benign musculoskeletal lipomatous lesions. Radiographics 2004;24:1433-66.
10. Greco M, Mazzocchi M, Ribuffo D, Dessy LA, Scuderi N. Parosteal lipoma. Report of 15 new cases and a review of the literature. Ann Ital Chir 2013;84:229-35.
11. Rosenberg AE, Bridge JA. Lipoma of bone. In: Fletcher CD, Unni KK, Mertens F, editors. Pathology and Genetics of Tumours of the Soft Tissues and Bones. Lyon: IARC Press; 2002. p. 328-9.
12. Kawashima A, Magid D, Fishman EK, Hruban RH, Ney DR. Parosteal ossifying lipoma: CT and MR findings. J Comput Assist Tomogr 1993;17:147-50.
13. Seki N, Okada K, Miyakoshi N, Shimada Y, Nishida J, Itoi E, et al. Common peroneal nerve palsy caused by parosteal lipoma of the fibula. J Orthop Sci 2006;11:88-91.
14. Resnick D, editor. Tumor and tumor-like diseases. In: Diagnosis of Bone and Joint Disorders. 4th ed. Philadelphia, PA: Saunders; 1995. p. 3745-4128.
15. Dorfman HD. Miscellaneous mesenchymal tumors. In: Dorfman H, Czerniak B, editors. Bone Tumors. St Louis, Mo: Mosby; 1998. p. 913-48.
16. Petit MM, Swarts S, Bridge JA, Van de Ven WJ. Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. Cancer Genet Cytogenet 1998;106:18-23.
17. Kransdorf M, Murphey M. Lipomatous tumors. In: Imaging of Soft Tissue Tumors. Philadelphia, PA: Saunders; 1997. p. 57-101.
18. Obermann EC, Bele S, Brawanski A, Knuechel R, Hofstaedter F. Ossifying lipoma. Virchows Arch 1999;434:181-3.
19. Burt AM, Huang BK. Imaging review of lipomatous musculoskeletal lesions. SICOT J 2017;3:34.
20. Yu JS, Wei L, Becker W. MR imaging of a parosteal lipoma. J Clin Imaging 2000;24:15-8.
21. Balani A, Sankhe A, Dedhia T, Bhuta M, Lakhotia N, Yeshwante J, et al. Lump on back: A rare case of parosteal lipoma of scapula. Case Rep Radiol 2014;2014:169157.
22. Go T, Nakajima N, Yokota N, Yokomise H. Thoracoscopic resection of parosteal lipoma of the rib using orthopedic electric micro drill. Gen Thorac Cardiovasc Surg 2018;66:675-8.


How to Cite this article: Sboui I, Riahi H, Chelli-Bouaziz M, Daghfous MS, Ladeb MF, Farah F. Parosteal Lipoma of the Lower Limb: A Report of Two Cases. Journal of Bone and Soft Tissue Tumors Jan-Apr 2019;5(1): 21-24.


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Health-Related Quality of Life in Patients with Bone Tumor around the Knee after Resection Arthrodesis

Vol 5 | Issue 1 | Jan-April 2019 | page: 17-20 | Wilasinee Sirichativapee, Weerachai Kosuwon, Winai Sirichativapee.


Authors: Wilasinee Sirichativapee [1], Weerachai Kosuwon [1], Winai Sirichativapee [1].

[1] Department of Orthopaedics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Address of Correspondence
Dr. Winai Sirichativapee,
Department of Orthopaedics, Srinagarind Hospital, 123 Khon Kaen University, Nai Mueang Sub-District, Mueang District, Khon Kaen Province – 40002, Thailand.
E-mail: winaisiri@yahoo.com


Abstract

Background: This study aimed to compare the health-related quality of life (HRQoL) of patient with bone tumor around the knee after resection arthrodesis.
Methods: Patients between 15 and 70 years of age who underwent resection arthrodesis in Srinagarind Hospital >1 year were recruited. Patients were interviewed using a short form-36 questionnaire (social functioning-36 [SF-36] Ver2.0 Thai version) regarding their daily life problems.
Results: Eighteen patients with the mean age of 36.6 years (15–63 years) were included (15 females) in the study. Histological diagnoses were giant cell tumor 10 cases, osteosarcoma seven cases, and low-grade chondrosarcoma one case. Site of lesions was distal femur 15 cases and proximal tibia 3 cases. According to HRQoL, patients have good quality of life (score SF-36 >70) in all domains: Mean score: Physical functioning 75.55 ± 21.88, role physical 71.18 ± 22.70, bodily pain 85.41 ± 22.51, vitality 77.43 ± 16.76, general health 74.44 ± 19.16, SF 83.05 ± 26.40, role emotional 80.09 ± 22.89, and mental health 77.77 ± 21.29. Complications post-operative are broken implants (3 cases, 16.7%) and infections (4 cases, 22.2%).
Conclusion: In patients with bone tumor around the knee after resection, arthrodesis has a good quality of life in all domains in SF-36 version 2.0 questionnaire including function, pain, and mentality.
Keywords: Limb salvage, Arthrodesis, Quality of life, social functioning-36 version 2.0, Osteosarcoma, Giant cell tumor.


References

1. Tarnawska-Pierścińska M, Hołody Ł, Braziewicz J, Królicki L. Bone metastases diagnosis possibilities in studies with the use of 18F-NaF and 18F-FDG. Nucl Med Rev Cent East Eur 2011;14:105-8.
2. Sampath SC, Sampath SC, Mosci C, Lutz AM, Willmann JK, Mittra ES, et al. Detection of osseous metastasis by 18F-NaF/18F-FDG PET/CT versus CT alone. Clin Nucl Med 2015;40:e173-7.
3. Harisankar CN, Agrawal K, Bhattacharya A, Mittal BR. F-18 fluoro-deoxy-glucose and F-18 sodium fluoride cocktail PET/CT scan in patients with breast cancer having equivocal bone SPECT/CT. Indian J Nucl Med 2014;29:81-6.
4. Roop MJ, Singh B, Singh H, Watts A, Kohli PS, Mittal BR, et al. Incremental value of cocktail 18F-FDG and 18F-NaF PET/CT over 18F-FDG PET/CT alone for characterization of skeletal metastasesin breast cancer. Clin Nucl Med 2017;42:335-40.
5. Chan HP, Hu C, Yu CC, Huang TC, Peng NJ. Added value of using a cocktail of F-18 sodium fluoride and F-18 fluorodeoxyglucose in positron emission tomography/computed tomography for detecting bony metastasis: A case report. Medicine (Baltimore) 2015;94:e687.
6. Iagaru A, Mittra E, Mosci C, Dick DW, Sathekge M, Prakash V, et al. Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: Results of an international multicenter trial. J Nucl Med 2013;54:176-83.
7. Gradishar WJ, Anderson BO, Balassanian R, Blair SL, Burstein HJ, Cyr A, et al. NCCN Clinical Practice Guidelines in Oncology Breast Cancer Version 2; 2016. Available from: https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf. [Last accessed on 2016 Oct 19].
8. Yoon SH, Kim KS, Kang SY, Song HS, Jo KS, Choi BH, et al. Usefulness of (18)F-fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases. Nucl Med Mol Imaging 2013;47:27-35.
9. Israel O, Goldberg A, Nachtigal A, Militianu D, Bar-Shalom R, Keidar Z, et al. FDG-PET and CT patterns of bone metastases and their relationship to previously administered anti-cancer therapy. Eur J Nucl Med Mol Imaging 2006;33:1280-4.
10. Lapa P, Saraiva T, Silva R, Marques M, Costa G, Lima JP. Superiority of 18F-Fna PET/CT for detecting bone metastases in comparison with other diagnostic ımaging modalities. Acta Med Port 2017;30:53-60.
11. Araz M, Aras G, Küçük ÖN. The role of 18F-NaF PET/CT in metastatic bone disease. J Bone Oncol 2015;4:92-7.
12. Schirrmeister H, Glatting G, Hetzel J, Nüssle K, Arslandemir C, Buck AK. Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med 2001;42:1800-4.
13. Piccardo A, Puntoni M, Morbelli S, Massollo M, Bongioanni F, Paparo F, et al. 18F-FDG PET/CT is a prognostic biomarker in patients affected by bone metastases from breast cancer in comparison with 18F-naF PET/CT. Nuklearmedizin 2015;54:163-72.
14. Iagaru A, Young P, Mittra E, Dick DW, Herfkens R, Gambhir SS. Pilot prospective evaluation of 99mTc-MDP scintigraphy, 18F NaF PET/CT, 18F FDG PET/CT and whole-body MRI for detection of skeletal metastases. Clin Nucl Med 2013;38:e290-6.
15. Hillner BE, Siegel BA, Hanna L, Duan F, Quinn B, Shields AF. 18F-fluoride PET used for treatment monitoring of systemic cancer therapy: Results from the national oncologic PET registry. J Nucl Med 2015;56:222-8.
16. Iagaru A, Mittra E, Dick DW, Gambhir SS. Prospective evaluation of (99m)Tc MDP scintigraphy, (18)F NaF PET/CT, and (18)F FDG PET/CTfor detection of skeletal metastases. Mol Imaging Biol 2012;14:252-9.


How to Cite this article: Koç Z P, Kara P Ö, Sezer E, Erçolak V.Diagnostic Comparison of F-18 Sodium FluorideNaF, Bone Scintigraphy, and F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Detection of Bone Metastasis. Journal of Bone and Soft Tissue Tumors Jan-Apr 2019;5(1): 17-20.

               


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Guest Editorial: Message from IMSOS President

Vol 5 | Issue 1 | Jan-April 2019 | page: 2 | Bhavin Jhankaria


Author: Bhavin Jhankaria [1].

[1] Picture This By Jankharia, Bhaveshwar Vihar, 383 Sardar V P Rd, Opposite Vanita Vishram, Mumbai, Maharashtra, 400004, India.

Address of Correspondence
Dr. Bhavin Jhankaria
Picture This By Jankharia, Bhaveshwar Vihar, 383 Sardar V P Rd, Opposite Vanita Vishram, Mumbai, Maharashtra, 400004, India.
Email: bhavin@jankharia.com


Asia Pacific Musculoskeletal Tumor Society Conference 2018

Message from IMSOS President

IMSOS or the Indian Musculoskeletal Oncology Society is truly a multi-disciplinary society comprising of orthopedic surgeons, radiologists, pathologists and medical and radiation oncologists. All of these specialties and their doctors have come together to work towards providing optimal care to patients with bone and soft tissue tumors. IMSOS also encourages non-doctor members…anyone who makes a difference to the care of patients with bone and soft tissue tumors is welcome to be part of the society.
IMSOS’ vision is to “promote scientific, evidence based, comprehensive multidisciplinary management of bone and soft tissue sarcomas and encourage basic and clinical research”. IMSOS’ mission is to do this through meetings, conferences, workshops, white papers and an active website where people engage with each other to learn and teach and to eventually use that knowledge to optimally manage patients and alleviate their pain and suffering.
IMSOS is orthopedic-surgeon-driven given the very nature of the subject. However, radiologists, pathologists, oncologists and the other members are also an integral part of the Society. By electing me President for the next 2 years, IMSOS has truly proven its multi-disciplinary character.
The new IMSOS secretary and I, will ensure that IMSOS’ mission and vision are fulfilled and that we continue the work done by Ajay Puri and Ashish Gulia. We will strive to create a platform that will allow those who come after us to continue and enhance the work done by us.
We are actively soliciting suggestions from IMSOS’ members on various topics and issues to ensure that IMSOS stays and continues to be relevant and make a difference.
Let’s have a great meeting in Kolkata and work towards an equally good or better meeting in Bengaluru in March 2020.

Dr Bhavin Jhankaria
President – Indian Musculo Skeletal Oncology Society


How to Cite this article: Jhankaria B. Message from IMSOS President. Journal of Bone and Soft Tissue Tumors Jan-April 2019; 5(1):2.


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Diagnostic Comparison of F-18 Sodium FluorideNaF, Bone Scintigraphy, and F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Detection of Bone Metastasis

Vol 5 | Issue 1 | Jan-April 2019 | page: 9-12 | Zehra PınarP Koç, Pelin Ö Kara, Emel Sezer, Vehbi Erçolak


Authors: Zehra PınarP Koç [1], Pelin Ö Kara [1], Emel Sezer [2], Vehbi Erçolak [2]

[1] Department of Nuclear Medicine, Mersin University, Mersin/, Turkey.,
[2] Department of Oncology, Mersin University, Mersin, Turkey. Mersin/Turkey.

Address of Correspondence
Dr. Zehra PınarP ınar Koç,
Mersin University Nuclear Medicine Dpt., Mersin – 33343, Turkey.
E-mail: zehrapinarkoc@gmail.com


Abstract

Objective: The aim of this study is to compare the diagnostic efficiency of bone scintigraphy, fluorodeoxyglucose (FDG), and sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) in the evaluation of bone metastasis of the several malignant tumors.
Materials and Methods: A total of Thirteen13 patients (9nine Ffemales and, 4four Mmales; mean 62,.3 ± 7,.1 years) with diagnosis of different malignant tumors were included in the study. The comparison of bone scintigraphy, FDG, and NaF PET/CT results were was performed retrospectively.
Results: The NaF PET/CT demonstrated all the metastatic patients in this series; however, FDG PET/CT missed 7/13 and bone scintigrapyhy 1/13 of the patients with bone metastasis. NaF PET/CT showed significantly higher number of metastatic lesions in all the patients.
Conclusion: The lesion- based analysis showed that NaF PET/CT is significantly superior to FDG PET/CT and bone scintigraphy and patient- based analysis lower detection rate for the FDG PET/CT.
Keywords: Bone, scintigraphy, metastasis, sodium fluorideNaF, fluorodeoxyglucosefdg.


References

1. Tarnawska-Pierścińska M, Hołody Ł, Braziewicz J, Królicki L. Bone metastases diagnosis possibilities in studies with the use of 18F-NaF and 18F-FDG. Nucl Med Rev Cent East Eur 2011;14:105-8.
2. Sampath SC, Sampath SC, Mosci C, Lutz AM, Willmann JK, Mittra ES, et al. Detection of osseous metastasis by 18F-NaF/18F-FDG PET/CT versus CT alone. Clin Nucl Med 2015;40:e173-7.
3. Harisankar CN, Agrawal K, Bhattacharya A, Mittal BR. F-18 fluoro-deoxy-glucose and F-18 sodium fluoride cocktail PET/CT scan in patients with breast cancer having equivocal bone SPECT/CT. Indian J Nucl Med 2014;29:81-6.
4. Roop MJ, Singh B, Singh H, Watts A, Kohli PS, Mittal BR, et al. Incremental value of cocktail 18F-FDG and 18F-NaF PET/CT over 18F-FDG PET/CT alone for characterization of skeletal metastasesin breast cancer. Clin Nucl Med 2017;42:335-40.
5. Chan HP, Hu C, Yu CC, Huang TC, Peng NJ. Added value of using a cocktail of F-18 sodium fluoride and F-18 fluorodeoxyglucose in positron emission tomography/computed tomography for detecting bony metastasis: A case report. Medicine (Baltimore) 2015;94:e687.
6. Iagaru A, Mittra E, Mosci C, Dick DW, Sathekge M, Prakash V, et al. Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: Results of an international multicenter trial. J Nucl Med 2013;54:176-83.
7. Gradishar WJ, Anderson BO, Balassanian R, Blair SL, Burstein HJ, Cyr A, et al. NCCN Clinical Practice Guidelines in Oncology Breast Cancer Version 2; 2016. Available from: https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf. [Last accessed on 2016 Oct 19].
8. Yoon SH, Kim KS, Kang SY, Song HS, Jo KS, Choi BH, et al. Usefulness of (18)F-fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases. Nucl Med Mol Imaging 2013;47:27-35.
9. Israel O, Goldberg A, Nachtigal A, Militianu D, Bar-Shalom R, Keidar Z, et al. FDG-PET and CT patterns of bone metastases and their relationship to previously administered anti-cancer therapy. Eur J Nucl Med Mol Imaging 2006;33:1280-4.
10. Lapa P, Saraiva T, Silva R, Marques M, Costa G, Lima JP. Superiority of 18F-Fna PET/CT for detecting bone metastases in comparison with other diagnostic ımaging modalities. Acta Med Port 2017;30:53-60.
11. Araz M, Aras G, Küçük ÖN. The role of 18F-NaF PET/CT in metastatic bone disease. J Bone Oncol 2015;4:92-7.
12. Schirrmeister H, Glatting G, Hetzel J, Nüssle K, Arslandemir C, Buck AK. Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med 2001;42:1800-4.
13. Piccardo A, Puntoni M, Morbelli S, Massollo M, Bongioanni F, Paparo F, et al. 18F-FDG PET/CT is a prognostic biomarker in patients affected by bone metastases from breast cancer in comparison with 18F-naF PET/CT. Nuklearmedizin 2015;54:163-72.
14. Iagaru A, Young P, Mittra E, Dick DW, Herfkens R, Gambhir SS. Pilot prospective evaluation of 99mTc-MDP scintigraphy, 18F NaF PET/CT, 18F FDG PET/CT and whole-body MRI for detection of skeletal metastases. Clin Nucl Med 2013;38:e290-6.
15. Hillner BE, Siegel BA, Hanna L, Duan F, Quinn B, Shields AF. 18F-fluoride PET used for treatment monitoring of systemic cancer therapy: Results from the national oncologic PET registry. J Nucl Med 2015;56:222-8.
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How to Cite this article: PKoç Z P, Kara P Ö, Sezer E, Erçolak V.Diagnostic Comparison of F-18 Sodium FluorideNaF, Bone Scintigraphy, and F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Detection of Bone Metastasis. Journal of Bone and Soft Tissue Tumors Jan-Apr 2019;5(1): 9-12.


                 


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