Vol 4 | Issue 2 | July-Dec 2018 | Page 25-26 | Sujit Joshi, Yogesh Panchwagh.
Authors: Sujit Joshi , Yogesh Panchwagh .
 Dept. of Pathology Deenanath Mangeshkar Hospital and Research Centre, Pune
 Orthopaedic Oncology Clinic, Pune, India.
Address of Correspondence
Dr. Sujit Joshi,
Dept. of Pathology Deenanath Mangeshkar Hospital and Research Centre, Pune
Osseous hydatid disease is rare, and it is even rare to see it in extremities or pelvis. At times these lesions present as destructive lesions on radiographs and mimic neoplasm. Here we present two such cases, one arising in the lower end of femur mimicking chondrosarcoma and required excision and surgical stabilization. Second case presented as a cystic lesion in iliac bone suggestive of aneurysmal bone cyst. Both are quite unusual presentation and hydatid disease should always be kept in differential while dealing with such lesion
Keywords: Osseous hydatid disease, chondrosarcoma, aneurysmal bone cyst
1. International Journal of Research in Medical Sciences; Kumar R et al. Int J Res Med Sci. 2017 Mar;5(3):1126-1130.
2. M Laubscher et al SA Orthopedic Journal Winter 2018, Page 44-48.
3. Dahniya MH, Hanna RM, Ashebu S, Muhtaseb SA, el-Beltagi A, Badr S, et al. The imaging appearances of hydatid disease at some unusual sites. Br J Radiol. 2001;74:283-9.
4. Mattern CJ, Gardner MJ, Grose A, Helfet DL. Echinococcus disease of the bone presenting as a femoral shaft non-union. ClinOrthopRelat Res. 2007;458:220-5.
|How to Cite this article: Joshi S, Panchwagh Y. Osseous Hydatid Disease: Mimicker of primary bone neoplasms.: Report of 2 cases. Journal of Bone and Soft Tissue Tumors July-Dec 2018;4(2): 25-26.|
Vol 4 | Issue 2 | July-Dec 2018 | Page 23-24 | Praveen Kumar Pandey, Raaghav Rai Verma.
Authors: Praveen Kumar Pandey , Raaghav Rai Verma .
 Esi-pgimsr model hospital basaidarapur new Delhi – 110015 , GGSIPU university
 Department of orthopaedics, Dr RML Hospital, new Delhi
Address of Correspondence
Dr. Praveen Pandey,
ESI-pgimsr Model Hospital Basaidarapur new Delhi – 110015 , GGSIPU university, India
Periosteal chondroma is a rare bone tumor. This is a slow growing benign cartilaginous tumor of bone. It is rarely reported in literature among Asian population. A 35 years old female presented to orthopaedics OPD with dull aching pain and mild swelling over volar aspect right forearm. Patient advised to undergo radiographs and MRI which showed the evidence of periosteal chondroma over anteromedial aspect right radius diaphysis. Hereby we are reporting our case of periosteal chondroma of radius- a rare pathology at rare location. Patient was operated with marginal excision and showed no recurrence during 2 year follow up.
Keywords: periosteal chondroma; rare; radius; asian; marginal excision.
1. Keiller VH. Cartilaginous tumors of bone. Surg Gynecol Obstet 1925; 40: 510.
2. Lichtenstein L, Hall J. Periosteal chondroma: a distinctive benign cartilage tumor. J Bone Joint Surg Am 1952; 34-A: 691-7.
3. Boriani S, Bacchini P, Bertoni F, Campanacci M. Periosteal chondroma. A review of twenty cases. J Bone Joint Surg Am 1983; 65: 205-12.
4. deSantos LA, Spjut HJ. Periosteal chondroma: a radiographic spectrum. Skeletal Radiol 1981; 6: 15-20.
5. Nojima T, Unni KK, McLeod RA, Pritchard DJ. Periosteal chondroma and periosteal chondrosarcoma Am J Surg Pathol 1985; 9: 666-77.
6. Sinha S, Singhania GK, Campbell AC. Periosteal chondroma of the distal radius. J Hand Surg [Br ] 1999; 24: 747-9.
7. Lisanti M, Buongiorno L, Bonicoli E, Cantini G. Periosteal chondroma of the proximal radius: a case report. Chir Organi Mov. 2005 Oct-Dec;90(4):403-7.
8. Parodi KK, Farrett W, Paden MH, Stone PA. A report of a rare phalangeal periosteal chondroma of the foot. J Foot Ankle Surg. 2011 Jan-Feb;50(1):122-5.
9. Al-Qudah AS, Abu-Ali HM, Al-Hussaini MA, Massad IM. Periosteal chondroma of the clavicle: case report and review of the literature. Int J Surg. 2009 Apr;7(2):140-1.
10. Sirichai Luevitoonvechkij , Olarn Arphornchayanon, Taninnit Leerapun , Songsak Khunsree. Periosteal Chondroma of the Proximal Humerus: A Case Report and Review of the Literature J Med Assoc Thai 2006;89(11): 1970-75.
11. Woertler K, Blasius S, Brinkschmidt C, Hillmann A, Link TM, Heindel W. Periosteal chondroma: MR characteristics. J Comput Assist Tomogr 2001; 25: 425-30.
12. Lewis MM, Kenan S, Yabut SM, Norman A, Steiner G. Periosteal chondroma. A report of ten cases and review of the literature. Clin Orthop Relat Res 1990; 185-92.
13. Bauer TW, Dorfman HD, Latham JT Jr. Periosteal chondroma. A clinicopathologic study of 23 cases. Am J Surg Pathol 1982; 6: 631-7.
14. Nosanchuk JS, Kaufer H. Recurrent periosteal chondroma. Report of two cases and a review of the literature. J Bone Joint Surg Am 1969; 51: 375-80.
15. Rockwell MA, Saiter ET, Enneking WF. Periosteal chondroma. J Bone Joint Surg Am 1972; 54: 102-8.
16. Bertoni F, Boriani S, Laus M, Campanacci M. Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities. J Bone Joint Surg Br 1982; 64: 370-6.
17. Lorente MF, Bonete Lluch DJ, Marti PV. Childhood periosteal chondroma. Arch Orthop Trauma Surg 2000; 120: 605-8.
18. Mora R, Guerreschi F, Fedeli A, Alfarano M, Angi V. Two cases of periosteal chondroma. Acta Orthop Scand 1988; 59: 723-7.
19. Ricca RL Jr, Kuklo TR, Shawen SB, Vick DJ, Schaefer RA. Periosteal chondroma of the cuboid presenting in a 7-year-old-boy. Foot Ankle Int 2000; 21: 145-9.
|How to Cite this article: Pandey PK, Verma RR. Periosteal Chondroma of Radius Diaphysis – Rare Presentation. Journal of Bone and Soft Tissue Tumors July-Dec 2018;4(2): 23-24.|
Vol 4 | Issue 2 | July-Dec 2018 | Page 20-22 | Sijin K S, Bhaskar Subin Sugath, Vijaya Mohan S, Vinod Kumar P, Nanda Kachare.
Authors: Sijin K S , Bhaskar Subin Sugath , Vijaya Mohan S , Vinod Kumar P , Nanda Kachare .
 Dept of Aster Orthopaedics, Aster Medcity, Cochin, India
Address of Correspondence
Dr. Bhaskar Subin Sugath,
Consultant, Aster Pathology, Aster Medcity, Cochin, India
A 35yr old female patient presented with a pulsatile swelling of right proximal tibia present for 2 years. There was a rapid increase in size and pain in the 6 weeks preceding presentation. Radiographs showed a lytic lesion of about 8cm x 8cm in the anteromedial aspect of the proximal tibia with MRI showing a highly vascular lesion. A needle biopsy and histopathological examination confirmed the diagnosis of Glomangioma. It was treated with marginal resection of the tumour and fibular grafting of the defect.
1. Shugart RR, Soule EH, Johnson EW Jr. Glomus tumor. Surg Gynecol Obstet, 1963; 117:334–340.
2. Schoen FJ, Cotran RS. The blood vessels. In: Kumar V, Cotran RS, Robins SL, editors. Robins Basic Pathology. Philadelphia: Saunders, 2003;325-36
3. Bhaskaranand K, Navadgi BC. Glomus tumour of the hand. J Hand Surg [Br] 2002;27:229-31.
4. Ozdemir O, Coskunol E, Ozalp T, et al. Glomus tumors of the finger: a report on 60 cases. Acta Orthop Traumatol Turc 2003;37:244-8.
5. Bahk WJ, Mirra JM, Anders KH. Intraosseous glomus tumor of the fibula. Skeletal Radiol 2000;29:708-12.
6. Settakorn J, Chalidapong P, Rangdaeng S, et al. Primary intraosseous glomus tumor: a case report. J Med Assoc Thai 2001;84:1641-5.
7. Weiss SW, Goldblum JR. Perivascular tumors. In Soft tissue tumors. 4th edition. pp.985–1035, 2001, Mosby, St Louis.
8. Kransdorf MJ, Murphey MD. Vascular and lymphatic tumors. In Imaging of soft tissue tumors. 2nd edition. pp. 150–188, 2006, Lippincott Williams & Wilkins, Philadelphia.
9. Rozmaryn LM, Sadler AH, Dorfman HD. Intraosseous glomus tumor in the ulna: a case report. Clin Orthop, 1987; 220: 126–129.
10. Urakawa H, Nakashima H, Yamada Y et al. Intraosseous glomus tumor of the ulna: A case report with radiographic findings and a review of the literature Nagoya J. Med. Sci. 70. 127 ~ 133, 2008.
11. Bessho Y, Kataoka O, Sho T, Kitazawa S, Okada S. Intraosseous glomus tumor in the upper thoracic spine complicating compression myelopathy: a case report. Spine, 1991; 16: 988–990.
12. Bjorkengren AG, Resnick D, Haghighi P, Sartoris DJ. Intraosseous glomus tumor: report of a case and review of the literature. AJR, 1986; 147: 739–741.
13. Chan CW. Intraosseous glomus tumor: case report. J Hand Surg, 1981; 6A: 368–369.
14. Johnson DL, Kuschner SH, Lane CS. Intraosseous glomus tumor of the phalanx: a case report. J Hand Surg, 1993; 18A: 1026–1028.
15. Kobayashi Y, Kawaguchi T, Imoto K, Yamamoto T. Intraosseous glomus tumor in the sacrum: a case report. Acta Pathol Jpn, 1990; 40: 856–859.
16. Mackenzie DH. Intraosseous glomus tumours. Report of two cases. J Bone Joint Surg, 1962; 44B: 648–651.
17. Payer M, Grob D, Benini A, Varga S, Hodler J, Martin JB. Intraosseous glomus tumor of the thoracic spine. Case illustration. J Neurosurg, 2002; 96: 137.
18. Robinson JC, Kilpatrick SE, Kelly DL Jr. Intraosseous glomus tumor of the spine: case report and review of the literature. J Neurosurg, 1996; 85: 344–347.
|How to Cite this article: Sijin KS, Sugath BS, Vijaya MS, Vinod KP, Kachare N. Glomangioma of the Tibia- A rare presentation . Journal of Bone and Soft Tissue Tumors July-Dec 2018;4(2): 20-22.|
Vol 4 | Issue 2 | July-Dec 2018 | Page 14-19 | Kala Gnanasekaran Kiruthiga, Anne Jennifer Prabhu, Rekha Pai, Sramana Mukhopadhyay, Reka.K, V.T.K.Titus, Selvamani Backianathan.
Authors: Kala Gnanasekaran Kiruthiga , Anne Jennifer Prabhu , Rekha Pai , Sramana Mukhopadhyay , Reka.K , V.T.K.Titus , Selvamani Backianathan .
 Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
 Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.
 Department of Orthopaedics, Christian Medical College, Vellore, Tamil Nadu, India.
 Department of Radiotherapy, Christian Medical College, Vellore, Tamil Nadu, India.
Address of Correspondence
Dr. Anne Jennifer Prabhu,
Address: Department of Pathology, ASHA Building, Christian Medical College, Vellore, Tamil Nadu, India.
Context: Synovial sarcoma is one of the commonly encountered spindle cell sarcomas of soft tissue. However, Biphasic synovial sarcoma (BSS) is a rare subtype of synovial sarcoma with limited literature on clinical profile, molecular characteristics and survival outcome.
Aims: We propose to describe the immuno – morphology, clinical features, molecular profile and outcome of patients with BSS.
Settings and Design: This retrospective study included 13 cases of BSS, 3.2% of all synovial sarcomas diagnosed over 10 years in our institute. The clinico-pathological features were studied in detail and immunohistochemistry for TLE-1, EMA, CD34, CD99 and S100 was done. Real time PCR and DNA sequencing for the common translocations (SYT-SSX1/ SYT-SSX2) were performed.
Statistical analysis used: Statistical Package for Social Services (SPSS) software Version 21.0 (Armonk, NY: IBM Corp).
Results: BSS was most commonly seen in young, the most common site being soft tissue of extremities (92.3%). 53.8% of patients presented at Enneking stage IIB. The FNCLCC grade varied between 2(46.2%) and 3(53.8%). All cases were positive for EMA and TLE-1; negative for CD34 and S100. Ten of the eleven (90.9%) patients tested had SYT-SSX1 translocation. Over a period of 8 to 46 months, 53.8% cases were alive and well with no evidence of disease; three had (30%) recurred, one (10%) had lung metastasis and one (10%) died.
Conclusions: BSS is most common in extremities. The immunohistochemical profile matches that of monophasic synovial sarcoma. FNCLCC grade is 2 to 3; however the grade does not correlate with clinical outcome. Most cases show SYT-SSX1 translocation. 53.8% cases were alive and well after a mean follow up of 20 months.
Keywords: Biphasic, follow-up, immunoprofile, SYT-SSX1, synovial sarcoma.
Keyword: Biphasic synovial sarcoma has the same immunoprofile as the monophasic subtype. All patients who tested positive had SYT-SSX1 translocation. More than 50% of patients were alive and well after 20 months.
1. Herzog CE. Overview of sarcomas in the adolescent and young adult population. J Pediatr Hematol Oncol 2005;27:215–8.
2. Suurmeijer AJH, de Bruijn D, Geurts van Kessel A, Miettinen MM. Tumours of uncertain differentiation. In: Fletcher C.D.M, Bridge JA, Hogendoorn P.C.W, Mertens F, editors. WHO Classification of Tumours of Soft Tissue and Bone, 4th edn. IARC: Lyon; 2013.p. 213-5.
3. Terry J, Saito T, Subramanian S, Ruttan C, Antonescu CR, Goldblum JR et al. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol 2007;31:240–6.
4. Christopher D.M.Fletcher. Tumours of soft tissue. In: Fletcher. C.D.M, editor. Diagnostic Histopathology of Tumors, 4th edn. Philadelphia: Saunders – Elsevier; 2013.p. 1847-9.
5. Goldblum JR, Folpe AL, Enzinger FM, Weiss SW. Malignant Soft Tumours of Uncertain Type. In: Enzinger and Weiss’s soft tissue tumors, 6th edn. Philadelphia: Saunders – Elsevier; 2014.p. 1052 – 70.
6. Coindre JM, Trojani M, Contesso G, David M, Rouesse J, Bui NB et al. Reproducibility of a histopathologic grading system for adult soft tissue sarcoma. Cancer 1986;58:306–9.
7. Guillou L, Benhattar J, Bonichon F, Gallagher G, Terrier P, Stauffer E et al. Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. J Clin Oncol 2004; 22: 4040-50.
8. Krieg AH, Hefti F, Speth BM, Jundt G, Guillou L, Exner UG et al. Synovial sarcomas usually metastasize after >5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors. Ann Oncol 2011;22:458-67.
9. Trojani M, Contesso G, Coindre JM, Rouesse J, Bui NB, de Mascarel A et al. Soft-tissue sarcomas of adults – study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer 1984;33:37–42.
10. Ferrari A, De Salvo GL, Brennan B, van Noesel MM, De Paoli A, Casanova M et al. Synovial sarcoma in children and adolescents: the European pediatric Soft tissue sarcoma Study Group prospective trial (EpSSG NRSTS 2005) Ann Oncol 2015;26 :567–72.
11. Ladanyi M, Antonescu CR, Leung DH, Woodruff JM, Kawai A, Healey JH et al. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res 2002;62:135–40.
12. Mallen-St Clair J, Arshi A, Abemayor E, St John M. Factors Associated With Survival in Patients With Synovial Cell Sarcoma of the Head and Neck: An Analysis of 167 Cases Using the SEER (Surveillance, Epidemiology, and End Results) Database. JAMA Otolaryngol– Head Neck Surg 2016;142:576–83.
13. Osma U, Eyigor H, Suren D, Sezer C, Yilmaz MD. Biphasic synovial sarcoma of the hypopharynx. Ear Nose Throat J 2015;94:36–9.
14. Sharif MA, Mushtaq S, Mamoon N, Khadim MT, Asghar Z. Biphasic synovial sarcoma of oral cavity. J Coll Physicians Surg–Pak JCPSP 2008;18:713–5.
15. Hazelbag HM, Szuhai K, Tanke HJ, Rosenberg C, Hogendoorn PCW. Primary synovial sarcoma of the heart: a cytogenetic and molecular genetic analysis combining RT-PCR and COBRA-FISH of a case with a complex karyotype. Mod Pathol Off J U S Can Acad Pathol Inc 2004;17:1434–9.
16. Jun L, Ke S, Zhaoming W, Linjie X, Xinru Y. Primary synovial sarcoma of the prostate: report of 2 cases and literature review. Int J Surg Pathol 2008;16:329–34.
17. Makhlouf HR, Ahrens W, Agarwal B, Dow N, Marshalleck JJ, Lee EL et al. Synovial sarcoma of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 10 cases. Am J Surg Pathol 2008;32:275–81.
18. Vera J, García M-D, Marigil M, Abascal M, Lopez J-I, Ligorred L. Biphasic synovial sarcoma of the abdominal wall. Virchows Arch Int J Pathol 2006;449:367–72.
19. Guillou L, Wadden C, Kraus MD, Tos APD, Fletcher CDM. S-100 Protein Reactivity in Synovial Sarcomas—a Potentially Frequent Diagnostic Pitfall. Appl Immunohistochem 1996;4:167–75.
20. Olsen SH, Thomas DG, Lucas DR. Cluster analysis of immunohistochemical profiles in synovial sarcoma, malignant peripheral nerve sheath tumor, and Ewing sarcoma. Mod Pathol 2006;19:659-68.
21. Hui P, Li N, Johnson C, De Wever I, Sciot R, Manfioletti G et al. HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor. Mod Pathol 2005;18:1519-26.
22. Cleven AH, Sannaa GA, Briaire-de Bruijn I, Ingram DR, van de Rijn M, Rubin BP et al. Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival. Mod Pathol 2016 J;29:582-90.
23. Pelmus M, Guillou L, Hostein I, Sierankowski G, Lussan C, Coindre J-M. Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)- positive cases. Am J Surg Pathol 2002;26:1434–40.
24. Dei Tos AP, Calonje E, Sciot R, Pauwels P, Knight JC, Dal Cin P et al. Immunohistochemical demonstration of glycoprotein p30/32MIC2 (CD99) in synovial sarcoma. A potential cause of diagnostic confusion. App Immunhistochem 1995;3:168-73.
|How to Cite this article: Kiruthiga KG, Anne Jennifer P, Rekha P, Sramana M, Reka.K, V.T.K.Titus, Selvamani B.. Biphasic synovial sarcoma – A ten year experience with molecular profile and clinical outcome. Journal of Bone and Soft Tissue Tumors July-Dec 2018;4(2): 14-19.|
Vol 4 | Issue 2 | July-Dec 2018 | Page 11-13 | Mahfooz Basha Mohamed, Jayasree Kattoor, Kusumakumary Parukuttyamma, Geetha Narayanan, Anitha Mathews, Thara Somanathan.
Authors: Mahfooz Basha Mohamed , Jayasree Kattoor , Kusumakumary Parukuttyamma , Geetha Narayanan , Anitha Mathews , Thara Somanathan .
 Department of Laboratory Medicine, GKNM Hospital, Coimbatore 641006, Tamil Nadu, India.
 Department of Pathology, Regional Cancer Centre, Trivandrum 695011, Kerala, India.
 Department of Paediatric Oncology, Regional Cancer Centre, Trivandrum 695011, Kerala, India.
 Department of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, Kerala.
Address of Correspondence
Department of Pathology, Regional Cancer Centre, Trivandrum-695011, Kerala, India.
Osteosarcoma is the most common primary malignant tumor of bone, usually arising from the metaphysis of the long bones around the knee joint. In 6-13% cases they are located in the head and neck region, of which maxilla and mandible are the most common sites. Osteosarcoma involving the extra-gnathic craniofacial bones account for less than 2% cases. We report eight such cases of osteosarcoma involving this unusual location in the last three years (2011 -2014) and present their clinicopathological profile. Seven patients were under 15 years of age and one patient was 37 years old. Out of the eight cases, four were males and four were females. The location of the tumor included occipital bone, parietal bone, external auditory canal, nasal bone and mastoid. Two patients presented as multicenteric disease with multiple lesions in the skull and elsewhere. Two patients succumbed to the disease while five patients are on follow up. One patient was lost to follow up.A complete en-bloc dissection of the tumor with free margins is a challenge for the operating surgeons. Radiologically they can simulate non-neoplastic lesions or benign tumors as well.These tumors pose a unique therapeutic challenge owing to their unusual location and require a multidisciplinary team approach for management of the patient.
Keywords: Extragnathic, skull, bone, osteosarcoma.
1. G. Ottaviani and N. Jaffe, The epidemiology of osteosarcoma. Cancer Treatment and Research, 2009; Vol. 152, pp. 3–13.
2. Oda D, Bavisotto L M, Schmidt R A. et al., Head and neck osteosarcoma at the University of Washington. Head Neck. 1997; 19(6):513–523.
3. Santhosh Kumar N, Elizabeth Mathew Iype, Shaji Thomas, JayasreeK,SivaramanGanesan.Osteogenic sarcoma of mastoid bone. Journal of Case Reports 2014; 4(2):334-337.
4. Fletcher CD, Bridge J, Hogendoorn PC, Mertens F, Eds. The World Health Organization Classification of Tumours of Soft Tissue and Bone. Lyon, France: IARC; 2013.
5. Jo, Vickie Y. et al. Refinements in Sarcoma Classification in the Current 2013 World Health Organization Classification of Tumours of Soft Tissue and Bone Surgical Oncology Clinics , Volume 25 , Issue 4 , 621 – 643.
6. Corradi D. et al.,Multicentric Osteosarcoma: Clinicopathologic and Radiographic Study of 56 Cases, American Journal of Clinical Pathology, Volume 136, Issue 5, 1 November 2011, Pages 799–807.
7. Hoch M, Ali S, Agrawal S, Wang C, Khurana JS. Extra skeletal Osteosarcoma: A case report and review of the literature. Radiology Case. 2013; 7(7):15-23.
8. Jasnau S, Meyer U, Potratz J, et al. Craniofacial osteosarcoma: experience of the cooperative German-Austrian-Swiss osteosarcoma study group. Oral Oncol 2008; 44(March (3)):286–94.
9. VijayaKamble, KajalMitra, ChetanaRatnaparkhi, AkshayKapila. Primary Osteogenic Sarcoma of Zygomatic Arch: A Case Report, with World Literature Review. Journal of Evolution of Medical and Dental Sciences 2014; Vol. 3, Issue 36, August 18; Page: 9494-9499, DOI: 10.14260/jemds/2014/3226.
10. Hadley C, Gressot LV, Patel AJ, Wang LL, Flores RJ, Whitehead WE, et al. Osteosarcoma of the cranial vault and skull base in pediatric patients. J NeurosurgPediatr 2014; 13: 380-5.
11. Brad W. Neville, Douglas D. Damm, Angela C. Chi, Carl M. Allen.Oral and Maxillofacial Pathology 4th Edition,Elsevier Health Sciences;2015.Chapter 14:p.614.
12. Horvai A, Unni KK. Premalignant conditions of bone. Journal of Orthopaedic Science. 2006; 11(4):412-423.
13. Gon S, Kundu T, Ghosh BN. Synchronous multifocal osteosarcoma with small cell histological variant: A double rarity. Clin Cancer Investig J 2016; 5:533-6.
14. Currall VA, Dixon JH. Synchronous multifocal osteosarcoma: Case report and literature review. Sarcoma 2006; 2006:53901.
15. Mathkour M, Garces J, Beard B, et al. Primary high-grade osteosarcoma of the clivus: a case report and literature review. World Neurosurg 2016; 89:730.e9–13.
16. Meel R, Thulkar S, Sharma MC, Jagadesan P, Mohanti BK, Sharma SC, et al: Childhood osteosarcoma of greater wing of sphenoid: case report and review of literature. J PediatrHematolOncol 34:e59–e62, 2012.
17. Thiele OC, Freier K, Bacon C, et al. Interdisciplinary combined treatment of craniofacial osteosarcoma with neoadjuvant and adjuvant chemotherapy and excision of the tumour: a retrospective study. Br J Oral MaxillofacSurg 2008;46:533-6.
|How to Cite this article: Mohamed MB, Kattoor J, Parukuttyamma K, Narayanan G, Mathews A, Somanathan T. Osteosarcoma of Extragnathic Skull Bones-clinicopathological Profile of Eight Cases. Journal of Bone and Soft Tissue Tumors July-Dec 2018;4(2): 11-13.|
Vol 4 | Issue 2 | July-Dec 2018 | Page 7-10 | Ashwini Natekar, Gaurav Gupta, Subhasis Basu.
Authors: Ashwini Natekar , Gaurav Gupta , Subhasis Basu .
 Dept of Pathology, Chittaranjan national cancer institute, Kolkata, India
Address of Correspondence
Dr. Ashwini Natekar,
Dept of Pathology, Chittaranjan national cancer institute, Kolkata, India
Introduction: Bone and soft tissue tumours are uncommon tumours that can affect any age group. Soft tissue tumors are said to be heterogeneous group of mesenchymal malignancies. Primary bone sarcomas are rare tumors, comprising approximately 0.2% of all cancers. Their true incidence is difficult to estimate because of their rarity.The outcome of the disease depends on the age and time at diagnosis.
Material and Methods: A study was carried out in department of pathology in tertiary cancer institute in East India from December 2015 to September 2017. A total of 60 cases were included in the study. Clinical and radiological details of patients were noted along with gross specimen findings and microscopic examination of H &E stained slides. IHC was also carried out for confirmatory diagnosis.
Aims and Objecctives: 1- To study the histological spectrum of bone and soft tissue tumors in a tertiary cancer institute in Eastern India
2- To study gender distribution and site distributionof bone and soft tissue tumors
Results: Out of the total 60 cases studied 24 cases were of bone and cartilaginous tumours and 36 cases included were of soft tissue tumors. Benign tumors comprised of 08 cases (13.3%) and malignant tumors accounted to 52 cases (86.7%). Age of the patients ranged from 10 to 80 years. Male female ratio was 1.4:1.
Conclusion: Multimodal therapies of treatment is practiced for bone and soft tissue tumors. Early detection and treatment is essential for diagnosis of these malignant tumors. Molecular studies are most important in diagnosing, classifying and also prognosticating bone and soft tissue tumors.
Keywords: bone tumors, soft tissue tumors, histology.
1. Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, et al., editors. SEER Cancer Statistics Review. Bethesda, MD: National Cancer Institute; 1975-2013. [Last accessed on 2016 Jun 01].
2. Jain P, Shrivastava A, Mallik R..Clinicomorphological Assessment of Soft Tissue Tumors. Sch J App Med Sci. 2014; 2(2D): p. 886-90.
3. Hassawi BA, Suliman AY, Hasan IS. Soft tissue tumours – Histopathological study of 93 cases. Ann Coll Med Mo sul.2-010; 36(1&2) : p. 92-8.
4. Weiss SW, Goldblum JR. General Considerations. In Enzinger & Weiss’s Soft Tissue Tumours, 4th edition.: Mosby Publication 2001; 20011-19.
5. Beg S, Vasenwala SM, Haider N, Ahmad SS,Maheshwari V, Khan MA. A comparison of cytological ad histopathological findings and role of immunostains in the diagnosis of soft tissue. J Cytol. 2012; 29(2): p. 125-130.
6. Lazim AF, Bedoor AK, Al-Irhayim. Soft tissue sarcomas in Mosul: a pathologic evaluation. Ann Coll Med Mosul. 20-08;34(2): p. 152-160.
7. Zhi-wei F, Jing C, Sheng T, Yong C, Rui-feng X. Analysis of soft tissue sarcomas in 1118 cases. Chinese Medical Journal.2009; 122(1): p. 51-53.
8. Batra P, Gupta DO, Batra R, Kothari R, Bokariya P.Pattern of Soft Tissue Tumours In A Rural Population Of Central India.Innovative Journal of Medical and Health Science. 2013 May – June; 3(3): p. 124-6.
9. Anant Ramaswamy, Bharat Rekhi,1 Sameer Bakhshi,2 Sachin Hingmire,3 and Manish Agarwal4Indian data on bone and soft tissue sarcomas: A summary of published study resultsSouth Asian Journal of Cancer.
10. Mark A. Applebaum, et al; Clinical features and outcomes in patients with extraskeletal Ewing sarcoma Cancer. 2011 Jul 1; 117(13): 3027–3032.
11. Askin FB, Rosai J, Sibley RK, Dehner LP, Mc Alister WH. Malignant small cell tumour of the thoracopulmonary region in childhood: a distinctive clinicopathologic entity of uncertain histogenesis. Cancer. 1979;43:2438–2451. doi: 10.1002/1097-0142(197906)43:6<2438::AID-CNCR2820430640>3.0.CO;2-9. [PubMed] [Cross Ref]
12. Sabati JM, Franquet T, Parellada JA, Monill JM, Oliva E. Malignant neuroectodermal tumour of the chest wall (Askin tumour): CT and MR findings in eight patients. Clinical Radiology. 1994;49:634–638. doi: 10.1016/S0009-9260(05)81882-3. [PubMed] [Cross Ref]
13. Winer-Muram HT, Kaufman WH, Gronemeyer SA, Gregory JS. Primitive neuroectodermal tumors of the chest wall (Askin tumors). CT and MR findings. Am J Res. 1985;145:517–520.
14. Dewan M, Malatani TS, Ansari MA. Lessons to be learned: A case study approach Malignant melanoma of soft tissue. J R Soc Health. 2005;125:42–6. [PubMed]
15. Crowson A, Magro C, Mihm M. Unusual histologic and clinical variants of melanoma: Implications for therapy. Curr Oncol Rep. 2007;9:403–10. [PubMed]
16 Lucas DR, Nascimento AG, Sim FH. Cell sarcoma of soft tissues: Mayo Clinic experience with 35 cases. Am J Surg Pathol. 1992;16:1197–204. [PubMed]
17. Enzinger FM. Clear cell sarcoma of tendons and aponeuroses: An analysis of 21 cases. Cancer. 1965;18:1163–76. [PubMed]
18. AF Mavrogenis,1 G Bianchi,2 NA Stavropoulos,1 PJ Papagelopoulos,1 and P Ruggieri2 Clinicopathological features, diagnosis and treatment of clear cell sarcoma/melanoma of soft parts Hippokratia. 2013 Oct-Dec; 17(4): 298–302.
19. Meis Kindblom JM. Clear cell sarcoma of tendons and aponeuroses: A historical perspective and tribute to the man behind the entity. Adv Anat Pathol. 2006;13:286–92. [PubMed]
20. O. Hocar,1 A. Le Cesne,2 S. Berissi,1 P. Terrier,2 S. Bonvalot,2 D. Vanel,3 A. Auperin,4 C. Le Pechoux,2 B. Bui,5 J. M. Coindre,5 and C. Robert1Clear Cell Sarcoma (Malignant Melanoma) of Soft Parts: A Clinicopathologic Study of 52 Cases:Dermatology Research and Practice
|How to Cite this article: Ashwini Natekar A, Gupta G, Basu S. Spectrum of Bone and Soft Tissue Tumors in A Tertiary Cancer Institute in Eastern India. Journal of Bone and Soft Tissue Tumors July – Dec 2018;4(2): 7-10.|