Vol 5 | Issue 1 | Jan-April 2019 | page: 9-12 | Zehra P\u0131narP Ko\u00e7, Pelin \u00d6 Kara, Emel Sezer, Vehbi Er\u00e7olak<\/p>\n

Authors: Zehra P\u0131narP Ko\u00e7 [1], Pelin \u00d6 Kara [1], Emel Sezer [2], Vehbi Er\u00e7olak [2<\/span>]<\/span><\/h3>\n

[1] Department of Nuclear Medicine, Mersin University, Mersin\/, Turkey.,
\n[2] Department of Oncology, Mersin University, Mersin, Turkey. Mersin\/Turkey.<\/p>\n

Address of Correspondence<\/span><\/strong>
\nDr. Zehra P\u0131narP \u0131nar Ko\u00e7,
\nMersin University Nuclear Medicine Dpt., Mersin \u2013 33343, Turkey.
\nE-mail: zehrapinarkoc@gmail.com<\/p>\n

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Abstract<\/strong><\/span><\/h3>\n

Objective:<\/strong> The aim of this study is to compare the diagnostic efficiency of bone scintigraphy, fluorodeoxyglucose (FDG), and sodium fluoride (NaF) positron emission tomography\/computed tomography (PET\/CT) in the evaluation of bone metastasis of the several malignant tumors.
\nMaterials and Methods:<\/strong> A total of Thirteen13 patients (9nine Ffemales and, 4four Mmales; mean 62,.3 \u00b1 7,.1 years) with diagnosis of different malignant tumors were included in the study. The comparison of bone scintigraphy, FDG, and NaF PET\/CT results were was performed retrospectively.
\nResults<\/strong>: The NaF PET\/CT demonstrated all the metastatic patients in this series; however, FDG PET\/CT missed 7\/13 and bone scintigrapyhy 1\/13 of the patients with bone metastasis. NaF PET\/CT showed significantly higher number of metastatic lesions in all the patients.
\nConclusion:<\/strong> The lesion- based analysis showed that NaF PET\/CT is significantly superior to FDG PET\/CT and bone scintigraphy and patient- based analysis lower detection rate for the FDG PET\/CT.
\nKeywords:<\/strong> Bone, scintigraphy, metastasis, sodium fluorideNaF, fluorodeoxyglucosefdg.<\/p>\n

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References<\/span><\/h3>\n

1. Tarnawska-Pier\u015bci\u0144ska M, Ho\u0142ody \u0141, Braziewicz J, Kr\u00f3licki L. Bone metastases diagnosis possibilities in studies with the use of 18F-NaF and 18F-FDG. Nucl Med Rev Cent East Eur 2011;14:105-8.
\n2. Sampath SC, Sampath SC, Mosci C, Lutz AM, Willmann JK, Mittra ES, et al. Detection of osseous metastasis by 18F-NaF\/18F-FDG PET\/CT versus CT alone. Clin Nucl Med 2015;40:e173-7.
\n3. Harisankar CN, Agrawal K, Bhattacharya A, Mittal BR. F-18 fluoro-deoxy-glucose and F-18 sodium fluoride cocktail PET\/CT scan in patients with breast cancer having equivocal bone SPECT\/CT. Indian J Nucl Med 2014;29:81-6.
\n4. Roop MJ, Singh B, Singh H, Watts A, Kohli PS, Mittal BR, et al. Incremental value of cocktail 18F-FDG and 18F-NaF PET\/CT over 18F-FDG PET\/CT alone for characterization of skeletal metastasesin breast cancer. Clin Nucl Med 2017;42:335-40.
\n5. Chan HP, Hu C, Yu CC, Huang TC, Peng NJ. Added value of using a cocktail of F-18 sodium fluoride and F-18 fluorodeoxyglucose in positron emission tomography\/computed tomography for detecting bony metastasis: A case report. Medicine (Baltimore) 2015;94:e687.
\n6. Iagaru A, Mittra E, Mosci C, Dick DW, Sathekge M, Prakash V, et al. Combined 18F-fluoride and 18F-FDG PET\/CT scanning for evaluation of malignancy: Results of an international multicenter trial. J Nucl Med 2013;54:176-83.
\n7. Gradishar WJ, Anderson BO, Balassanian R, Blair SL, Burstein HJ, Cyr A, et al. NCCN Clinical Practice Guidelines in Oncology Breast Cancer Version 2; 2016. Available from: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/breast.pdf. [Last accessed on 2016 Oct 19].
\n8. Yoon SH, Kim KS, Kang SY, Song HS, Jo KS, Choi BH, et al. Usefulness of (18)F-fluoride PET\/CT in breast cancer patients with osteosclerotic bone metastases. Nucl Med Mol Imaging 2013;47:27-35.
\n9. Israel O, Goldberg A, Nachtigal A, Militianu D, Bar-Shalom R, Keidar Z, et al. FDG-PET and CT patterns of bone metastases and their relationship to previously administered anti-cancer therapy. Eur J Nucl Med Mol Imaging 2006;33:1280-4.
\n10. Lapa P, Saraiva T, Silva R, Marques M, Costa G, Lima JP. Superiority of 18F-Fna PET\/CT for detecting bone metastases in comparison with other diagnostic \u0131maging modalities. Acta Med Port 2017;30:53-60.
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\n12. Schirrmeister H, Glatting G, Hetzel J, N\u00fcssle K, Arslandemir C, Buck AK. Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med 2001;42:1800-4.
\n13. Piccardo A, Puntoni M, Morbelli S, Massollo M, Bongioanni F, Paparo F, et al. 18F-FDG PET\/CT is a prognostic biomarker in patients affected by bone metastases from breast cancer in comparison with 18F-naF PET\/CT. Nuklearmedizin 2015;54:163-72.
\n14. Iagaru A, Young P, Mittra E, Dick DW, Herfkens R, Gambhir SS. Pilot prospective evaluation of 99mTc-MDP scintigraphy, 18F NaF PET\/CT, 18F FDG PET\/CT and whole-body MRI for detection of skeletal metastases. Clin Nucl Med 2013;38:e290-6.
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\n16. Iagaru A, Mittra E, Dick DW, Gambhir SS. Prospective evaluation of (99m)Tc MDP scintigraphy, (18)F NaF PET\/CT, and (18)F FDG PET\/CTfor detection of skeletal metastases. Mol Imaging Biol 2012;14:252-9.<\/p>\n

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How to Cite this article:<\/span><\/strong> PKo\u00e7 Z P, Kara P \u00d6, Sezer E, Er\u00e7olak V.Diagnostic Comparison of F-18 Sodium FluorideNaF, Bone Scintigraphy, and F-18 Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography in the Detection of Bone Metastasis. Journal of Bone and Soft Tissue Tumors Jan-Apr 2019;5(1): 9-12.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u200b<\/p>\n \n <\/a>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 <\/span><\/h3>\n \n (Abstract \u00a0 \u00a0Full Text HTML<\/a>)\u00a0 \u00a0(Download PDF<\/a>)<\/span><\/h3>\n \n <\/h3>\n","protected":false},"excerpt":{"rendered":" Vol 5 | Issue 1 | Jan-April 2019 | page: 9-12 | Zehra P\u0131narP Ko\u00e7, Pelin \u00d6 Kara, Emel Sezer, Vehbi Er\u00e7olak Authors: Zehra P\u0131narP Ko\u00e7 [1], Pelin \u00d6 Kara [1], Emel Sezer [2], Vehbi Er\u00e7olak [2] [1] Department of Nuclear Medicine, Mersin University, Mersin\/, Turkey., [2] Department of Oncology, Mersin University, Mersin, Turkey. Mersin\/Turkey. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_newsletter_tier_id":0,"footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[185],"tags":[189,193,191,190,192],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5rNta-1gT","jetpack_likes_enabled":true,"_links":{"self":[{"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/posts\/4891"}],"collection":[{"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/comments?post=4891"}],"version-history":[{"count":5,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/posts\/4891\/revisions"}],"predecessor-version":[{"id":5037,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/posts\/4891\/revisions\/5037"}],"wp:attachment":[{"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/media?parent=4891"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/categories?post=4891"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/tags?post=4891"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}