Vol 4 | Issue 2 | July-Dec 2018 | Page 14-19 | Kala Gnanasekaran Kiruthiga, Anne Jennifer Prabhu, Rekha Pai, Sramana Mukhopadhyay, Reka.K, V.T.K.Titus, Selvamani Backianathan.<\/p>\n

Authors: Kala Gnanasekaran Kiruthiga [1], Anne Jennifer Prabhu [1], Rekha Pai [1], Sramana Mukhopadhyay [1], Reka.K [2], V.T.K.Titus [3], Selvamani Backianathan [4].<\/span><\/h3>\n

[1] Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
\n[2] Department of Biostatistics,\u00a0Christian Medical College, Vellore, Tamil Nadu, India.
\n[3] Department of Orthopaedics,\u00a0Christian Medical College, Vellore, Tamil Nadu, India.
\n[4] Department of Radiotherapy, Christian Medical College, Vellore, Tamil Nadu, India.<\/p>\n

Address of Correspondence<\/span><\/strong>
\nDr. Anne Jennifer Prabhu,
\nAddress: Department of Pathology, ASHA Building, Christian Medical College, Vellore, Tamil Nadu, India.
\nE-mail: annejennifer91@gmail.com<\/p>\n

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Abstract<\/strong><\/span><\/h3>\n

Context:<\/span><\/strong> Synovial sarcoma is one of the commonly encountered spindle cell sarcomas of soft tissue. However, Biphasic synovial sarcoma (BSS) is a rare subtype of synovial sarcoma with limited literature on clinical profile, molecular characteristics and survival outcome.
\nAims:<\/span><\/strong> We propose to describe the immuno \u2013 morphology, clinical features, molecular profile and outcome of patients with BSS.
\nSettings and Design:<\/span><\/strong> This retrospective study included 13 cases of BSS, 3.2% of all synovial sarcomas diagnosed over 10 years in our institute. The clinico-pathological features were studied in detail and immunohistochemistry for TLE-1, EMA, CD34, CD99 and S100 was done. Real time PCR and DNA sequencing for the common translocations (SYT-SSX1\/ SYT-SSX2) were performed.
\nStatistical analysis used:<\/span><\/strong> Statistical Package for Social Services (SPSS) software Version 21.0 (Armonk, NY: IBM Corp).
\nResults:<\/span><\/strong> BSS was most commonly seen in young, the most common site being soft tissue of extremities (92.3%). 53.8% of patients presented at Enneking stage IIB. The FNCLCC grade varied between 2(46.2%) and 3(53.8%). All cases were positive for EMA and TLE-1; negative for CD34 and S100. Ten of the eleven (90.9%) patients tested had SYT-SSX1 translocation. Over a period of 8 to 46 months, 53.8% cases were alive and well with no evidence of disease; three had (30%) recurred, one (10%) had lung metastasis and one (10%) died.
\nConclusions:<\/span><\/strong> BSS is most common in extremities. The immunohistochemical profile matches that of monophasic synovial sarcoma. FNCLCC grade is 2 to 3; however the grade does not correlate with clinical outcome. Most cases show SYT-SSX1 translocation. 53.8% cases were alive and well after a mean follow up of 20 months.
\nKeywords: Biphasic, follow-up, immunoprofile, SYT-SSX1, synovial sarcoma.
\nKeyword:<\/span> <\/strong>Biphasic synovial sarcoma has the same immunoprofile as the monophasic subtype. All patients who tested positive had SYT-SSX1 translocation. More than 50% of patients were alive and well after 20 months.<\/p>\n

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References<\/span><\/h3>\n

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How to Cite this article:<\/span><\/strong> Kiruthiga KG, Anne Jennifer P, Rekha P, Sramana M, Reka.K, V.T.K.Titus, Selvamani B.. Biphasic synovial sarcoma \u2013 A ten year experience with molecular profile and clinical outcome. Journal of Bone and Soft Tissue Tumors July-Dec 2018;4(2): 14-19.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u200b<\/p>\n \n \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 (Abstract \u00a0 \u00a0Full Text HTML<\/a>) \u00a0 \u00a0 \u00a0(Download PDF<\/a>)<\/span><\/h3>\n \n <\/h3>\n","protected":false},"excerpt":{"rendered":" Vol 4 | Issue 2 | July-Dec 2018 | Page 14-19 | Kala Gnanasekaran Kiruthiga, Anne Jennifer Prabhu, Rekha Pai, Sramana Mukhopadhyay, Reka.K, V.T.K.Titus, Selvamani Backianathan. Authors: Kala Gnanasekaran Kiruthiga [1], Anne Jennifer Prabhu [1], Rekha Pai [1], Sramana Mukhopadhyay [1], Reka.K [2], V.T.K.Titus [3], Selvamani Backianathan [4]. [1] Department of Pathology, Christian Medical College, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_newsletter_tier_id":0,"footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[180],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5rNta-1bJ","jetpack_likes_enabled":true,"_links":{"self":[{"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/posts\/4571"}],"collection":[{"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/comments?post=4571"}],"version-history":[{"count":4,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/posts\/4571\/revisions"}],"predecessor-version":[{"id":5044,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/posts\/4571\/revisions\/5044"}],"wp:attachment":[{"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/media?parent=4571"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/categories?post=4571"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/jbstjournal.com\/wp-json\/wp\/v2\/tags?post=4571"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}